2022
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.Peer-Reviewed Original ResearchConceptsAcral melanomaMelanoma subtypesClinical profilingCommon melanoma subtypeImmune checkpoint blockadeCheckpoint blockadeInferior survivalMelanoma cell linesKey molecular driversPoor prognosisTherapeutic targetAnchorage-independent growthImmunomodulatory genesNon-white individualsHotspot mutationsMolecular driversCandidate oncogeneMelanomaApoptotic cell deathLZTR1Focal amplificationTumor promoterCell linesMetastasisTumor suppressor
2001
Surgical Considerations in the Management of Malignant Melanoma of the Ear
Narayan D, Ariyan S. Surgical Considerations in the Management of Malignant Melanoma of the Ear. Plastic & Reconstructive Surgery 2001, 107: 20-24. PMID: 11176596, DOI: 10.1097/00006534-200101000-00004.Peer-Reviewed Original ResearchConceptsMalignant melanomaLocal recurrenceYale-New Haven HospitalUnknown primary sitePrimary malignant melanomaPalpable nodesDisseminated diseaseRadical resectionConsecutive patientsLocal excisionRegional recurrenceWorse prognosisTransit melanomaConservative excisionSurgical considerationsSkin graftsDifficult lesionsFasciocutaneous flapPatientsPrimary siteMelanomaCosmetic importanceRecurrenceExternal earLesions
2000
Surgical Management Of The Primary Melanoma
Narayan D, Ariyan S. Surgical Management Of The Primary Melanoma. Clinics In Plastic Surgery 2000, 27: 409-419. PMID: 10941561, DOI: 10.1016/s0094-1298(20)32736-x.Peer-Reviewed Original ResearchRegional Lymph Node Dissections In Malignant Melanoma
Lawton G, Ariyan S. Regional Lymph Node Dissections In Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 431-440. PMID: 10941563, DOI: 10.1016/s0094-1298(20)32738-3.Peer-Reviewed Original ResearchConceptsElective lymph node dissectionLymph node dissectionNode dissectionNegative nodesTherapeutic lymph node dissectionRegional lymph node dissectionSentinel lymph node dissectionClinical stage ITime of resectionPositive nodesRegional lymphadenectomySentinel lymphProphylactic excisionCutaneous melanomaPrimary tumorMalignant melanomaPrimary melanomaRegional nodesSurvival advantageStage IPatientsMetastatic cellsMelanomaDissectionClear benefitLymphatic Mapping And Sentinel Lymph Node Biopsies
Ali-Salaam P, Ariyan S. Lymphatic Mapping And Sentinel Lymph Node Biopsies. Clinics In Plastic Surgery 2000, 27: 421-429. PMID: 10941562, DOI: 10.1016/s0094-1298(20)32737-1.Peer-Reviewed Original ResearchThe Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma
Ma D, Ariyan S. The Use Of Isolated Limb Perfusion To Manage Recurrent Malignant Melanoma. Clinics In Plastic Surgery 2000, 27: 441-450. PMID: 10941564, DOI: 10.1016/s0094-1298(20)32739-5.Peer-Reviewed Original ResearchConceptsRecurrent malignant melanomaMalignant melanomaLimb perfusionTumor necrosis factor alphaRecurrent metastatic diseaseIsolated limb perfusionNecrosis factor alphaList of drugsHyperthermic ILPRecurrent diseaseMetastatic diseaseTumor loadLimb functionClinical trialsSurgical techniqueFactor alphaWound hygieneChemotherapeutic agentsMelanomaPerfusionDiseaseExtremitiesTreatmentHyperthermicTrialsThe Rising Level of Medical Student Debt: Potential Risk for a National Default
Ariyan S. The Rising Level of Medical Student Debt: Potential Risk for a National Default. Plastic & Reconstructive Surgery 2000, 105: 1457-1464. PMID: 10744242, DOI: 10.1097/00006534-200004040-00031.Peer-Reviewed Original ResearchConceptsMedical studentsMedical educationEducational debtMedical student debtStudy of medicineFlexner ReportFuture physiciansStudent debtMajor universitiesStudentsNational defaultsEducationNational financial crisisResponsibilityInstitutionsSocial responsibilityFinancial responsibilityFinancial needsTeachingUniversityOwn familyNeedUnited StatesLeadersFunding
1999
Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma
Poo‐Hwu W, Ariyan S, Lamb L, Papac R, Zelterman D, Hu G, Brown J, Fischer D, Bolognia J, Buzaid A. Follow‐up recommendations for patients with American Joint Committee on Cancer Stages I–III malignant melanoma. Cancer 1999, 86: 2252-2258. PMID: 10590365, DOI: 10.1002/(sici)1097-0142(19991201)86:11<2252::aid-cncr12>3.0.co;2-q.Peer-Reviewed Original ResearchConceptsCancer stage IAmerican Joint CommitteePatient education programStage IYale Melanoma UnitSurveillance scheduleSymptomatic recurrenceMelanoma UnitSurveillance examinationsJoint CommitteeOverall survival rateStage of diseaseDetection of recurrenceAsymptomatic recurrenceAsymptomatic patientsDistant recurrenceLocoregional recurrenceHazard ratioDisease recurrenceInitial visitMore recurrencesMost recurrencesLate recurrenceMelanoma patientsRecurrence group
1998
Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients
Ariyan S, Poo W. Safety and efficacy of isolated perfusion of extremities for recurrent tumor in elderly patients. Surgery 1998, 123: 335-343. PMID: 9526527, DOI: 10.1016/s0039-6060(98)70188-6.Peer-Reviewed Original ResearchConceptsElderly patientsYounger patientsIsolated perfusionMeaningful disease controlRegional isolated perfusionEvidence of diseaseHigh-dose chemotherapySeries of patientsIsolated limb perfusionMajor surgical proceduresNumber of patientsDisease-free controlsYears of ageSalvage of limbsSignificant palliationThird perfusionAggressive treatmentDose chemotherapyOlder patientsRecurrent diseaseSurvival benefitTransit diseaseSerious complicationsRecurrent tumorsLimb perfusion
1997
Hypopharyngeal Cancer Patient Care Evaluation
Hoffman H, Karnell L, Shah J, Ariyan S, Brown G, Fee W, Glass A, Goepfert H, Ossoff R, Fremgen A. Hypopharyngeal Cancer Patient Care Evaluation. The Laryngoscope 1997, 107: 1005-1017. PMID: 9260999, DOI: 10.1097/00005537-199708000-00001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHypopharyngeal squamous cell carcinomaTreatment practicesDisease-specific survivalSquamous cell carcinomaFuture clinical trialsStandard of careCurrent treatment practicesPatient care evaluationCancer RegistryMedical chart informationClinical findingsCell carcinomaClinical trialsCare EvaluationDiagnostic proceduresChart informationSurgerySurvivalPatientsCarcinomaRegistryHospitalTrialsCareDemographicsPatterns of Care for Cancer of the Larynx in the United States
Shah J, Karnell L, Hoffman H, Ariyan S, Brown G, Fee W, Glass A, Goepfert H, Ossoff R, Fremgen A. Patterns of Care for Cancer of the Larynx in the United States. JAMA Otolaryngology - Head & Neck Surgery 1997, 123: 475-483. PMID: 9158393, DOI: 10.1001/archotol.1997.01900050021002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdvanced-stage patientsRadiation therapyRegional metastasesLaryngeal cancerStage IIIDisease-specific survival outcomesFive-year survival rateStage IV diseaseAmerican Joint CommitteeEarly-stage patientsSeries of patientsSquamous cell carcinomaPatterns of careCase-mix characteristicsRadiochemotherapy protocolHospital recordsN classificationNonsurgical treatmentTreatment patternsSurvival outcomesCell carcinomaTreatment characteristicsLarge seriesPatientsUS hospitalsRegional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard
Ariyan S, Poo W, Bolognia J. Regional Isolated Perfusion of Extremities for Melanoma: A 20-Year Experience with Drugs Other than L-Phenylalanine Mustard. Plastic & Reconstructive Surgery 1997, 99: 1023-1029. PMID: 9091898, DOI: 10.1097/00006534-199704000-00016.Peer-Reviewed Original ResearchConceptsL-phenylalanine mustardRegional isolated perfusionIsolated limb perfusionIsolated perfusionLimb perfusionUpper extremityLower extremitiesTherapeutic isolated limb perfusionNonfatal pulmonary embolusRegional treatment modalityEvidence of diseaseHigh-dose chemotherapyHigh-risk melanomaNumber of patientsDifficult management problemDisease-free controlsTechnique of perfusionLimb recurrenceMeaningful palliationRepeat perfusionsAggressive treatmentPulmonary emboliDose chemotherapyRecurrent melanomaSerious complicationsRestructuring academic departments of surgery at University Medical Centers
Ariyan S. Restructuring academic departments of surgery at University Medical Centers. The American Journal Of Surgery 1997, 173: 351-357. PMID: 9136796, DOI: 10.1016/s0002-9610(96)00385-6.Peer-Reviewed Original ResearchFurther Experiences with the Sternocleidomastoid Myocutaneous Flap: A Clinical Appraisal of 31 Cases
Ariyan S. Further Experiences with the Sternocleidomastoid Myocutaneous Flap: A Clinical Appraisal of 31 Cases. Plastic & Reconstructive Surgery 1997, 99: 61-69. PMID: 8982187, DOI: 10.1097/00006534-199701000-00009.Peer-Reviewed Original ResearchConceptsSternocleidomastoid myocutaneous flapOropharyngeal areaMyocutaneous flapConcomitant neck dissectionPrevious radiation therapyComplication rateNeck dissectionAdditional surgeryBlood supplyConsecutive reconstructionsRadiation therapyEpidermal lossClinical appraisalFurther experienceRegional flapsSmall woundsFlapReconstruction of the Head and Neck
Ariyan S, Ross D, Sasaki C. Reconstruction of the Head and Neck. Surgical Oncology Clinics Of North America 1997, 6: 1-43. PMID: 9031433, DOI: 10.1016/s1055-3207(18)30341-7.Peer-Reviewed Original Research
1996
General Principles of Reconstruction Following Cancer Surgery
Ariyan S. General Principles of Reconstruction Following Cancer Surgery. Surgical Oncology Clinics Of North America 1996, 5: 741-750. PMID: 8899943, DOI: 10.1016/s1055-3207(18)30351-x.ChaptersReconstructive Surgery in Melanoma Patients
Ariyan S. Reconstructive Surgery in Melanoma Patients. Surgical Oncology Clinics Of North America 1996, 5: 785-808. PMID: 8899945, DOI: 10.1016/s1055-3207(18)30353-3.ChaptersConceptsSurgical excisionFull-thickness skin graftingWide surgical excisionCost of hospitalizationSplit-thickness skinDepth of invasionEarly ambulationLocal recurrenceSurgical treatmentMelanoma patientsWide excisionWide resectionTumor thicknessCosmetic resultsPrimary closureFear of difficultySkin graftingMalignant melanomaReconstructive surgeryAnatomic sitesPrimary siteFurther experienceLocal flapsMethod of reconstructionExcisionProlonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection
Sasson H, Poo W, Bakas M, Ariyan S. Prolonged Survival in Patients with Advanced Melanoma Treated with Neoadjuvant Chemotherapy Followed by Resection. Annals Of Plastic Surgery 1996, 37: 286-292. PMID: 8883727, DOI: 10.1097/00000637-199609000-00009.Peer-Reviewed Original ResearchConceptsStart of chemotherapySite of metastasisSurgical resectionPerformance statusResidual metastasesNeoadjuvant chemotherapyCombination chemotherapyMetastatic melanomaRetrospective analysisCompletion of chemotherapyCycles of chemotherapyConcomitant medical problemsDistant lymph nodesInitiation of therapySimilar clinical characteristicsTreatment of choiceNew combination regimensSignificant survival advantageDuration of survivalHigh response rateStable diseaseRecurrent diseaseClinical characteristicsMedian durationPartial response
1995
Multiple Primary Melanomas
Ariyan S, Poo W, Bolognia J, Buzaid A, Ariyan T, Ariyan S. Multiple Primary Melanomas. Plastic & Reconstructive Surgery 1995, 96: 1384-1389. PMID: 7480238, DOI: 10.1097/00006534-199511000-00023.Peer-Reviewed Original ResearchConceptsSecond primary melanomaPrimary melanomaPrimary cutaneous melanomaMultiple primary melanomasIncidence of melanomaYale Melanoma UnitFirst malignancySubsequent melanomaFirst diagnosisPoor prognosisCutaneous melanomaMelanoma UnitPatient prognosisMultiple melanomasSubsequent lesionsPatientsInitial melanomaMelanomaPrognosisFirst yearSecond yearReportYearsMalignancyStatistics ReportManagement of carotid artery rupture by monitored endovascular therapeutic occlusion (1988‐1994)
Citardi M, Chaloupka J, Son Y, Ariyan S, Sasaki C. Management of carotid artery rupture by monitored endovascular therapeutic occlusion (1988‐1994). The Laryngoscope 1995, 105: 1086-1092. PMID: 7564841, DOI: 10.1288/00005537-199510000-00015.Peer-Reviewed Original ResearchConceptsCarotid ruptureNeurologic sequelaeBalloon occlusionEndovascular occlusion techniqueMajor neurologic sequelaeSignificant neurologic sequelaeCarotid artery rupturePermanent balloon occlusionDetachable balloon occlusionNeurologic morbidity rateWound complicationsArtery ruptureRadical surgeryEndovascular techniquesMorbidity ratePersistent carcinomaEtiologic factorsTherapeutic occlusionNeck surgeryOcclusion techniqueRadiation therapyPatientsOcclusionSequelaeSurgery