Stephanie O'Malley, PhD
Research & Publications
Biography
News
Research Summary
The goal of our laboratory is to develop more efficacious treatments for alcohol use disorders and nicotine dependence and to provide the science base for the regulation of tobacco products. Toward this end, we are conducting clinical trials to determine efficacy of medications and behavioral interventions, and laboratory studies to determine the mechanisms underlying the effects of treatment and the underlying nature of the disorder. Research on how flavors, such as methol and sweeteners, influence the use of tobacco products is underway to inform the regulation of tobacco products by the FDA.
Specialized Terms: Medications development for alcoholism and smoking; Risk reduction and young adult drinking; tobacco regulatory science; treatment methodology; patient treatment matching; biomarkers of treatment response
Extensive Research Description
Yale Tobacco Center for Regulatory Science
Clinical trials of varenicline for the treatment of alcohol dependence among smokers and of naltrexone for young adult heavy drinkers
Laboratory studies to evaluate medications for substance use disorders
Validation of biomarkers for monitoring drinking in clinical trials
Secondary analyses to identify moderators and predictors of response to treatments for alcohol dependence using tree based and trajectory analyses
Training of clinician and transdisciplinary scientists
Coauthors
Research Interests
Alcoholism; Psychiatry; Smoking; Substance-Related Disorders; Risk Reduction Behavior; Psychiatry and Psychology
Selected Publications
- Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trialHorvath M, Pittman B, O’Malley S, Grutman A, Khan N, Gueorguieva R, Brewer J, Garrison K. Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial. Annals Of Medicine 2024, 56: 2352803. PMID: 38823419, PMCID: PMC11146247, DOI: 10.1080/07853890.2024.2352803.
- How healthcare providers and the right information may play a critical role in quitting success among smokers interested in using e-cigarettes for quitting: Results from a survey of U.S adultsSharma A, King J, Krishnan-Sarin S, O’Malley S, Morean M, Bold K. How healthcare providers and the right information may play a critical role in quitting success among smokers interested in using e-cigarettes for quitting: Results from a survey of U.S adults. PLOS ONE 2024, 19: e0303245. PMID: 38753868, PMCID: PMC11098412, DOI: 10.1371/journal.pone.0303245.
- Varenicline for E-Cigarette Cessation in Adults: A Preliminary Placebo-Controlled Randomized TrialFucito L, Baldassarri S, Baker N, Palmer A, O'Malley S, Carpenter M, Krishnan-Sarin S, Gray K, Toll B. Varenicline for E-Cigarette Cessation in Adults: A Preliminary Placebo-Controlled Randomized Trial. American Journal Of Preventive Medicine 2024 PMID: 38752949, DOI: 10.1016/j.amepre.2024.04.007.
- Evidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot studyHaeny A, Schick M, McKenley C, Chowdhary A, Bellamy C, O'Malley S, Sinha R. Evidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study. Drug And Alcohol Dependence 2024, 260: 111312. PMID: 38749311, DOI: 10.1016/j.drugalcdep.2024.111312.
- Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorderGarcia C, Richards D, Tuchman F, Hallgren K, Kranzler H, Aubin H, O’Malley S, Mann K, Aldridge A, Hoffman M, Anton R, Witkiewitz K. Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder. Alcohol And Alcoholism 2024, 59: agae022. PMID: 38606931, PMCID: PMC11010310, DOI: 10.1093/alcalc/agae022.
- A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocolBold K, Sharma A, Haeny A, Gueorguieva R, Buta E, Baldassarri S, Lempert L, Krishnan-Sarin S, O’Malley S. A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol. BMC Psychiatry 2024, 24: 201. PMID: 38475757, PMCID: PMC10935798, DOI: 10.1186/s12888-024-05619-0.
- The Scientific Basis for the Regulation of Flavors in Tobacco ProductsBold K, Kong G, O'Malley S. The Scientific Basis for the Regulation of Flavors in Tobacco Products. Annual Review Of Clinical Psychology 2024, 20 PMID: 38346292, DOI: 10.1146/annurev-clinpsy-080921-075624.
- Impaired Control (Both Attempts to Control Drinking and Failed Control) as Prospective Predictors of Negative Outcomes among Young Adults who Drink Heavily.Leeman R, Berey B, Frohe T, Ferreiro A, O'Malley S. Impaired Control (Both Attempts to Control Drinking and Failed Control) as Prospective Predictors of Negative Outcomes among Young Adults who Drink Heavily. Journal Of Studies On Alcohol And Drugs 2024 PMID: 38315139, DOI: 10.15288/jsad.22-00362.
- Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorderTuchman F, Hallgren K, Richards D, Aldridge A, Anton R, Aubin H, Kranzler H, Mann K, O'Malley S, Witkiewitz K. Reductions in WHO risk drinking levels correlate with alcohol craving among individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2024, 48: 420-429. PMID: 38149364, PMCID: PMC10922776, DOI: 10.1111/acer.15257.
- Evidence of subgroup differences in meta‐analyses evaluating medications for alcohol use disorder: An umbrella reviewWallach J, Glick L, Gueorguieva R, O'Malley S. Evidence of subgroup differences in meta‐analyses evaluating medications for alcohol use disorder: An umbrella review. Alcohol Clinical And Experimental Research 2023, 48: 5-15. PMID: 38102794, PMCID: PMC10841726, DOI: 10.1111/acer.15229.
Clinical Trials
Conditions | Study Title |
---|---|
Addictive Behaviors; Alcohol Addiction | Brief training for 18-26 year olds: Regulation of alcohol craving |
Addictive Behaviors; Tobacco Addiction | Varenicline for treatment of e-cigarette dependence |
Tobacco Addiction | The interaction of flavor with nicotine form in adult smokers |
Mental Health & Behavioral Research | An fMRI study of responses to e-cigarette advertising and warnings among adolescents |