Featured Publications
Benchmarking transcriptional host response signatures for infection diagnosis
Chawla D, Cappuccio A, Tamminga A, Sealfon S, Zaslavsky E, Kleinstein S. Benchmarking transcriptional host response signatures for infection diagnosis. Cell Systems 2022, 13: 974-988.e7. PMID: 36549274, PMCID: PMC9768893, DOI: 10.1016/j.cels.2022.11.007.Peer-Reviewed Original ResearchConceptsInfection diagnosisHost response signatureNon-infectious conditionsClinical applicationResponse signatureChronic infectionPathogen of interestBacterial infectionsInfectionSignature of infectionDisease signaturesDiagnosisTranscriptional profilesStandardized methodologyDevelopment of signaturesDecreased performance
2016
Single cell variability in pro-inflammatory and antiviral gene responses in dendritic cells
Fribourg Casajuana M, Hartmann B, Tabbaa O, Ramos I, Zaslavsky E, Nudelman G, Albrecht R, Merad M, Hayot F, Jayaprakash C, Kleinstein S, Garcia-Sastre A, Sealfon S. Single cell variability in pro-inflammatory and antiviral gene responses in dendritic cells. The Journal Of Immunology 2016, 196: 202.29-202.29. DOI: 10.4049/jimmunol.196.supp.202.29.Peer-Reviewed Original ResearchDendritic cellsI IFNsI interferonImmune responsePeripheral Blood Plasmacytoid Dendritic CellsBlood plasmacytoid dendritic cellsMonocyte-derived dendritic cellsType I IFNsDendritic cell populationsPlasmacytoid dendritic cellsAppropriate immune responseHuman peripheral bloodType I interferonAntiviral gene responsesRIG-I inductionH1N1 virusAutoimmune diseasesPeripheral bloodChronic infectionNoxious stimuliViral infectionImmune signalsAntiviral ISGsCell responsesISG group