2020
Toward an Automatic System for Computer-Aided Assessment in Facial Palsy
Guarin D, Yunusova Y, Taati B, Dusseldorp J, Mohan S, Tavares J, van Veen M, Fortier E, Hadlock T, Jowett N. Toward an Automatic System for Computer-Aided Assessment in Facial Palsy. Facial Plastic Surgery & Aesthetic Medicine 2020, 22: 42-49. PMID: 32053425, PMCID: PMC7362997, DOI: 10.1089/fpsam.2019.29000.gua.Peer-Reviewed Original ResearchConceptsFacial landmark localizationLandmark localizationMachine learningML algorithmsFacial landmarksAutomatic systemComputer-aided diagnosis systemLocalization accuracyGraphical user interfaceCustom graphical user interfaceLandmark localization accuracyComputer-Aided AssessmentPoor localization accuracyUser interfaceDetection modelMore imagesDiagnosis systemML modelsAvailable algorithmsManual markingNovel ML algorithmsNovel ML modelsLarge databaseAlgorithm accuracyLocalization model
2019
Implantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timingStain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy
Mohan S, Hernández I, Selig M, Shibata S, Jowett N. Stain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy. Journal Of Neuropathology & Experimental Neurology 2019, 78: 1178-1180. PMID: 31642916, PMCID: PMC7967843, DOI: 10.1093/jnen/nlz099.Peer-Reviewed Original Research
2018
Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model
Mohan S, Hernández I, Wang W, Yin K, Sundback C, Wegst U, Jowett N. Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model. The Laryngoscope 2018, 128: e386-e392. PMID: 30098047, DOI: 10.1002/lary.27439.Peer-Reviewed Original ResearchConceptsHigh-throughput platformConduit performanceTissue processing stepsRobust axonal sproutingSciatic nerve transectionHigh throughputCryosection techniqueFluorescent reporter miceVivo mammalian modelsInterposition repairAxonal sproutingNerve transectionIsoflurane anesthesiaPeripheral neuronsAxonal ingrowthProcedure timeReporter miceNerve regenerationTransgenic miceVivo modelMiceMicroscopyVivo platformFluorescent proteinFluorescent microscopyLong-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children
Greene J, Tavares J, Mohan S, Jowett N, Hadlock T. Long-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children. The Journal Of Pediatrics 2018, 202: 279-284.e2. PMID: 30054167, DOI: 10.1016/j.jpeds.2018.06.043.Peer-Reviewed Original ResearchConceptsFree gracilis muscle transferFacial palsyGracilis muscle transferSmile excursionQuality of lifeMuscle transferPostoperative photographySmile reanimationFacial Clinimetric Evaluation (FaCE) surveyPatient-based instrumentLong-term outcomesCohort of childrenFacial nerve centerFacial symmetryPediatric patientsPostoperative qualityLife scoresTerm outcomesRetrospective analysisMassachusetts EyePalsySignificant improvementFacial impairmentPatientsFacial asymmetryOpioids and the Otolaryngologist: An Ambulatory Assessment
Mohan S, Bhattacharyya N. Opioids and the Otolaryngologist: An Ambulatory Assessment. Otolaryngology 2018, 159: 29-34. PMID: 29557264, DOI: 10.1177/0194599818765125.Peer-Reviewed Original ResearchConceptsOpioid prescriptionsOtolaryngology visitsOpioid prescribingCalendar trendsNational Ambulatory Medical Care SurveyAmbulatory Medical Care SurveyDesign Cross-sectional analysisOpioid medication prescribingOpioid prescription patternsChronic otitis mediaOpioid prescription ratesAmbulatory care settingsCross-sectional analysisOutpatient opioidsNational survey databasePrescription patternsNasal obstructionPrescription ratesMedication prescribingPostoperative careOtitis externaOtitis mediaCare SurveyOpioid epidemicCare settingsAssessment of Disease‐Specific and General Patient‐Reported Outcome Measures of Hearing Health
Mohan S, Corrales C, Yueh B, Shin J. Assessment of Disease‐Specific and General Patient‐Reported Outcome Measures of Hearing Health. Otolaryngology 2018, 158: 702-709. PMID: 29460681, DOI: 10.1177/0194599818757998.Peer-Reviewed Original ResearchConceptsPROMIS scoresTertiary care academic medical centerMental health summary scoresGlobal itemMental healthPhysical healthInner earProspective cohort dataDisease-specific assessmentsGeneral health statusHealth summary scoresComposite scoreItem scoresAcademic medical centerMean scoreChief complaintPROMIS instrumentsDisease-SpecificGeneral patientsHearing lossOutcome measuresMedical CenterMethods AdultsSummary scoresHealth status
2017
Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity
Mohan S, Pai S, Bhattacharyya N. Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity. The Laryngoscope 2017, 127: 1334-1338. PMID: 28150306, PMCID: PMC7388729, DOI: 10.1002/lary.26443.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Squamous CellCarcinoma, VerrucousCross-Sectional StudiesDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedMouthMouth NeoplasmsNeoplasm Recurrence, LocalRadiotherapy, AdjuvantSEER ProgramSquamous Cell Carcinoma of Head and NeckTreatment OutcomeConceptsAdjuvant radiation therapyDisease-specific survivalSquamous cell carcinomaVerrucous carcinomaRadiation therapyOverall survivalOral cavityVC patientsWorse OSCarcinoma patientsImproved overall survivalEnd Results (SEER) databaseKaplan-Meier survivalAdjuvant radiotherapySCC patientsLocal recurrenceResults databaseT stagePositive marginsSCC casesCell carcinomaPatientsSurgeryCarcinomaDifferent biology
2016
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Eytan D, Snow G, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers A, Hernandez L, Mitchell J, Annunziata C, Chen Z, Van Waes C. SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. Cancer Research 2016, 76: 5442-5454. PMID: 27469115, PMCID: PMC5026594, DOI: 10.1158/0008-5472.can-15-3317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBlotting, WesternCarcinoma, Squamous CellCell Line, TumorChemoradiotherapyDipeptidesFas-Associated Death Domain ProteinFemaleGene AmplificationGene Knockdown TechniquesHead and Neck NeoplasmsHumansImmunohistochemistryIndolesInhibitor of Apoptosis ProteinsMiceMice, Inbred BALB CMice, SCIDReal-Time Polymerase Chain ReactionSquamous Cell Carcinoma of Head and NeckTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaUbiquitin-Protein LigasesXenograft Model Antitumor AssaysConceptsSmac mimeticsCell deathNovel Smac mimeticsCaspase-dependent apoptosisExpression of FADDFrequent genomic amplificationCell cycle arrestBaculovirus inhibitorG2-M cell cycle arrestApoptosis repeatCancer Genome AtlasDeath domainIAP inhibitorsFunctional importanceSiRNA knockdownDNA fragmentationHNSCC cell linesFADDBirinapantGenomic amplificationGene transferGenome AtlasProtein markersComparison of tumorGenomic alterations
2015
MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
Bian Y, Han J, Kannabiran V, Mohan S, Cheng H, Friedman J, Zhang L, VanWaes C, Chen Z. MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer. International Journal Of Biological Sciences 2015, 11: 411-422. PMID: 25798061, PMCID: PMC4366640, DOI: 10.7150/ijbs.10745.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzamidesBlotting, WesternCasein Kinase IICell Line, TumorDiphenylamineFemaleFlow CytometryHead and Neck NeoplasmsHumansJNK Mitogen-Activated Protein KinasesMiceMice, Inbred BALB CMice, SCIDNaphthyridinesNF-kappa BPhenazinesProto-Oncogene Proteins c-fosTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsAnti-tumor activityMEK inhibitor PD-0325901PD-901CK2 inhibitor CXModest anti-tumor activityNeck squamous cell carcinomaPD-0325901Cell linesSignificant anti-tumor effectHuman HNSCC cell linesUM-SCC cell linesP-AKT T308Squamous cell carcinomaIL-8 activityFurther clinical investigationAnti-tumor effectsHNSCC cell linesDNA flow cytometryAP-1 pathwayDrug resistance mechanismsExhibit anti-tumor activityResistance mechanismsUM-SCC1Cell carcinomaNeck cancer
2014
A Case of Trigeminocardiac Reflex During Infrastructure Maxillectomy
Mohan S, Flis D, O'Leary M. A Case of Trigeminocardiac Reflex During Infrastructure Maxillectomy. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 563-564. PMID: 24788865, DOI: 10.1001/jamaoto.2014.562.Peer-Reviewed Original ResearchConceptsTrigeminocardiac reflexInfrastructure maxillectomyTertiary academic medical centerEpisodes of asystoleAdministration of atropineSquamous cell carcinomaAcademic medical centerArterial hypotensionSensory branchSkull base proceduresAnticholinergic useInciting stimulusCell carcinomaTrigeminal nerveTrigeminal branchesNeck surgeonsMedical CenterBetter outcomesCareful dissectionEarly interventionProcedure completionReflexMaxillectomySudden developmentBradycardia