2024
SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours
Lee P, Bishu S, Breze C, Chak A, Gardner T, Guda N, Kaul V, Muniraj T, Papachristou G, Schrope B, Spagnolo D, Strand D, Tarnasky P, Taylor J, Wilcox C, Whitcomb D. SMART Medical Review: Acute Pancreatitis Assessment and Management in the First 24 Hours. 2024, 1: e19-e48. DOI: 10.69734/7dcnna53.Peer-Reviewed Original ResearchPoint of careManagement of APClinical decision support toolQuality of careQuality improvement recommendationsGroup of clinical expertsAcute pancreatitisInnate inflammatory responseCareClinical expertsExpert recommendationsLife-threatening consequencesDecision support toolEarly treatmentPhysical examinationInflammatory responseInflammatory reactionRecommendationsSeveral determinantsIndividualized treatmentImprovement recommendationsSupport toolDiagnosisLaboratory testsTreatment
2023
Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence?
Magier S, Muniraj T, Merchant N. Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence? Cleveland Clinic Journal Of Medicine 2023, 90: 341-343. PMID: 37263664, DOI: 10.3949/ccjm.90a.22060.Peer-Reviewed Original ResearchConceptsInitial diagnostic workupAcute pancreatitisDiagnostic workupLipase testingPancreatitisInpatientsWorkup
2022
Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium
Singh V, Whitcomb D, Banks P, AlKaade S, Anderson M, Amann S, Brand R, Conwell D, Cote G, Gardner T, Gelrud A, Guda N, Forsmark C, Lewis M, Sherman S, Muniraj T, Romagnuolo J, Tan X, Tang G, Sandhu B, Slivka A, Wilcox C, Yadav D, Wilcox C, Guda N, Banks P, Conwell D, Lo S, Gelrud A, Gardner T, Baillie J, Forsmark C, Muniraj T, Sherman S, Singh V, Lewis M, Romagnuolo J, Hawes R, Cote G, Lawrence C, Anderson M, Amann S, Etemad B, DeMeo M, Kochman M, Abberbock J, Barmada M, Bauer E, Brand R, Kennard E, LaRusch J, O'Connell M, Stello K, Slivka A, Talluri J, Tang G, Whitcomb D, Wisniewski S, Yadav D, Burton F, AlKaade S, DiSario J, Sandhu B, Money M, Steinberg W. Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium. Pancreatology 2022, 22: 1091-1098. PMID: 36404201, PMCID: PMC10122210, DOI: 10.1016/j.pan.2022.10.004.Peer-Reviewed Original ResearchConceptsDiagnosis of CPAcute pancreatitisChronic pancreatitisCP diagnosisAP patientsAssociation of APNorth American Pancreatitis StudiesMajority of patientsMultivariable logistic regressionDisease-related factorsNorth American cohortClinical acute pancreatitisAP episodeAbdominal painSecondary preventionMultivariable analysisExocrine insufficiencyPancreatic atrophyMore episodesUS CentersWhite raceLower oddsPatientsAmerican cohortPancreatitisS13 Early Feeding Rates in Acute Pancreatitis Is Associated With Decreased Length of Hospitalization
Pascal M, Magier S, Nawaz A, Muniraj T, Hung K. S13 Early Feeding Rates in Acute Pancreatitis Is Associated With Decreased Length of Hospitalization. The American Journal Of Gastroenterology 2022, 117: e12-e12. DOI: 10.14309/01.ajg.0000856692.43734.28.Peer-Reviewed Original ResearchAcute pancreatitisDecreased length
2021
Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain
Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC, Consortium F. Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. The American Journal Of Gastroenterology 2021, 116: 2128-2136. PMID: 34236339, PMCID: PMC8531869, DOI: 10.14309/ajg.0000000000001366.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderChronic pancreatitisSevere painPain experienceThird of patientsPain management strategiesIdentification of patientsAbsence of painInflammatory syndromePain patternsCP patientsPain categoriesPain locusStudy cohortAcute pancreatitisAdrenal axisCP subjectsPainGenetic predispositionPatientsPsychiatric conditionsGenetic risk lociPTSD riskPancreatitisStress disorderResection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.Peer-Reviewed Original ResearchConceptsIntra-ductal papillary mucinous neoplasmRecurrent acute pancreatitisPancreatic cystic neoplasmsCystic neoplasmsBD-IPMNAcute pancreatitisCause of pancreatitisRole of resectionMucinous cystic neoplasmPrevalence of malignancyPapillary mucinous neoplasmSerous cystic neoplasmsCross-sectional imagingMean episodesRAP patientsSurgical resectionCyst resectionMD-IPMNPrimary outcomeIPMN patientsRecurrent pancreatitisRetrospective studyCyst featuresGallstone aetiologyMucinous neoplasmsTreatment of Acute Pancreatitis in The Emergency Room
Muniraj T, Vege S. Treatment of Acute Pancreatitis in The Emergency Room. 2021, 53-58. DOI: 10.1002/9781119570097.ch7.Peer-Reviewed Original ResearchHours of presentationAcute pancreatitisEmergency roomFluid resuscitationEarly aggressive fluid resuscitationUrgent endoscopic retrograde cholangiopancreatographyCommon gastrointestinal causesPrompt accurate diagnosisAggressive fluid resuscitationAcute abdominal painCornerstone of managementEndoscopic retrograde cholangiopancreatographyGastrointestinal causesAbdominal painProphylactic antibioticsHospital admissionRetrograde cholangiopancreatographySpecialist consultationCommon complaintEarly managementNatural coursePossible etiologiesPatient outcomesBetter outcomesFatal disease
2020
Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
Dunbar E, Greer PJ, Melhem N, Alkaade S, Amann ST, Brand R, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda NM, LaRusch J, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Wilcox CM, Singh VK, Yadav D, Whitcomb DC. Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort. Journal Of Gastroenterology 2020, 55: 1000-1009. PMID: 32681239, PMCID: PMC9124361, DOI: 10.1007/s00535-020-01703-w.Peer-Reviewed Original ResearchConceptsConstant severe painRecurrent acute pancreatitisChronic pancreatitisDepression-associated genesCP patientsPain severityAntidepressant usePancreatitis patientsPain experienceProspective randomized trialsAntidepressant medication usePattern of painCase report formsChronic opioidsIslet autotransplantationAntidepressant therapyTotal pancreatectomyMedication usePain managementRandomized trialsCounseling patientsRetrospective studyAcute pancreatitisClinical trialsMajor depression
2019
Su1418 – Role of Therapeutic Anticoagulation in Splanchnic Vein Thrombosis Associated with Acute Pancreatitis: A Systematic Review and Descriptive Analysis
McCarty T, Jamidar P, Aslanian H, Muniraj T. Su1418 – Role of Therapeutic Anticoagulation in Splanchnic Vein Thrombosis Associated with Acute Pancreatitis: A Systematic Review and Descriptive Analysis. Gastroenterology 2019, 156: s-540. DOI: 10.1016/s0016-5085(19)38246-0.Peer-Reviewed Original Research
2018
Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis
Coté GA, Yadav D, Abberbock JA, Whitcomb DC, Sherman S, Sandhu BS, Anderson MA, Lewis MD, Alkaade S, Singh VK, Baillie J, Banks PA, Conwell D, Guda NM, Muniraj T, Tang G, Brand R, Gelrud A, Amann ST, Forsmark CE, Wilcox C, Slivka A, Gardner TB. Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. The American Journal Of Gastroenterology 2018, 113: 906-912. PMID: 29867178, PMCID: PMC6136830, DOI: 10.1038/s41395-018-0087-7.Peer-Reviewed Original ResearchConceptsMental component summary scoresRecurrent acute pancreatitisLower physical component summaryPhysical component summaryQuality of lifeChronic pancreatitisAcute pancreatitisLower mental component summary scoresMental QOLLower QOLShort Form-12Component summary scoresCross-sectional studyMultivariable regression modelsNon-disease controlsEndocrine insufficiencyComponent summaryIndependent predictorsForm-12CP subjectsPancreatitisSummary scoresObjectivesThe impactU.S. CentersQOL predictorsKnown genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry
Phillips AE, LaRusch J, Greer P, Abberbock J, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Brand RE, Conwell D, Coté GA, Forsmark CE, Gardner TB, Gelrud A, Guda N, Lewis M, Money ME, Muniraj T, Sandhu BS, Sherman S, Singh VK, Slivka A, Tang G, Wilcox CM, Whitcomb DC, Yadav D. Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry. Pancreatology 2018, 18: 528-535. PMID: 29859674, PMCID: PMC8715541, DOI: 10.1016/j.pan.2018.05.482.Peer-Reviewed Original ResearchPathogenic genetic variantsRecurrent acute pancreatitisAA patientsAA subjectsGenetic variantsAfrican ancestryGenetic susceptibility factorsComplex risk factorsAfrican American subjectsNAPS2 studyAlcohol etiologyAcute pancreatitisChronic pancreatitisEA patientsCP subjectsRisk factorsAA casesPatientsPancreatitisSusceptibility factorsPrevalenceFurther studiesEA subjectsStructured questionnaireSPINK1
2015
PANCREATITIS OR NOT? – Elevated lipase and amylase in ICU patients
Muniraj T, Dang S, Pitchumoni CS. PANCREATITIS OR NOT? – Elevated lipase and amylase in ICU patients. Journal Of Critical Care 2015, 30: 1370-1375. PMID: 26411523, DOI: 10.1016/j.jcrc.2015.08.020.Peer-Reviewed Original ResearchConceptsAcute pancreatitisAssociated co-morbid conditionsIntensive care unit patientsCare unit patientsCo-morbid conditionsNon-pancreatic diseaseElevated lipaseClinical pancreatitisMost patientsUnit patientsICU patientsIll patientsSerum levelsICU settingPancreatitisPatientsPancreatic enzymesClinical diagnosisTypical symptomsDifferent causesDiseaseElevationHyperamylasemiaHyperlipasemiaAmylase
2012
Hypertriglyceridemia Independent Propofol-Induced Pancreatitis
Muniraj T, Aslanian HR. Hypertriglyceridemia Independent Propofol-Induced Pancreatitis. JOP Journal Of The Pancreas 2012, 13: 451-453. PMID: 22797405, DOI: 10.6092/1590-8577/822.Peer-Reviewed Original Research