2024
Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}
Wilcox C, Bang J, Buxbaum J, Gardner T, Hawes R, Kedia P, Mardini S, Muniraj T, Navaneethan U, Oza V, Tarnasky P, Thakkar S, Waxman I, Varadarajulu S. Effect of endoscopic ultrasound guided celiac plexus block on the palliation of pain in chronic pancreatitis (EPOCH Trial): study protocol for a randomized multicenter sham-controlled trial {1}. Trials 2024, 25: 676. PMID: 39396987, PMCID: PMC11472533, DOI: 10.1186/s13063-024-08478-y.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAutonomic Nerve BlockCeliac PlexusEndosonographyHumansMulticenter Studies as TopicNerve BlockPain MeasurementPalliative CarePancreatitis, ChronicProspective StudiesRandomized Controlled Trials as TopicTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsCeliac plexus blockAbdominal painChronic pancreatitisVisual analog scalePlexus blockSham-controlled trialRandomized sham-controlled trialEndoscopic ultrasound-guided celiac plexus blockEffectiveness of endoscopic ultrasoundBrief Pain Inventory Short FormDocumented chronic pancreatitisPainful chronic pancreatitisPalliation of painTime of EUSTreatment of abdominal painPain scoresBPI-SFSteroid combinationsAnalog scaleEndoscopic ultrasoundProspective studyCeliac plexusRandomized trialsShort formPancreatitis
2023
Advancing surveillance protocols for dysplastic Barrett’s esophagus after complete remission of intestinal metaplasia: Time to rethink biopsy strategy?
Burton S, Muniraj T. Advancing surveillance protocols for dysplastic Barrett’s esophagus after complete remission of intestinal metaplasia: Time to rethink biopsy strategy? Gastrointestinal Endoscopy 2023, 98: 733-734. PMID: 37863568, DOI: 10.1016/j.gie.2023.07.051.Peer-Reviewed Original ResearchEndoscopic Ultrasound in Cancer Staging
Aslanian H, Muniraj T, Nagar A, Parsons D. Endoscopic Ultrasound in Cancer Staging. Gastrointestinal Endoscopy Clinics Of North America 2023, 34: 37-49. PMID: 37973230, DOI: 10.1016/j.giec.2023.09.009.Peer-Reviewed Original ResearchSpontaneous Hyperinflation of Gastric Weight Loss Balloon
Mathialagan K, Parsons D, Muniraj T. Spontaneous Hyperinflation of Gastric Weight Loss Balloon. Digestive Diseases And Sciences 2023, 68: 4067-4068. PMID: 37676629, DOI: 10.1007/s10620-023-08092-z.Peer-Reviewed Original ResearchSerial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence?
Magier S, Muniraj T, Merchant N. Serial serum lipase testing after the initial diagnostic workup for inpatients with acute pancreatitis: What is the evidence? Cleveland Clinic Journal Of Medicine 2023, 90: 341-343. PMID: 37263664, DOI: 10.3949/ccjm.90a.22060.Peer-Reviewed Original Research
2022
Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium
Singh V, Whitcomb D, Banks P, AlKaade S, Anderson M, Amann S, Brand R, Conwell D, Cote G, Gardner T, Gelrud A, Guda N, Forsmark C, Lewis M, Sherman S, Muniraj T, Romagnuolo J, Tan X, Tang G, Sandhu B, Slivka A, Wilcox C, Yadav D, Wilcox C, Guda N, Banks P, Conwell D, Lo S, Gelrud A, Gardner T, Baillie J, Forsmark C, Muniraj T, Sherman S, Singh V, Lewis M, Romagnuolo J, Hawes R, Cote G, Lawrence C, Anderson M, Amann S, Etemad B, DeMeo M, Kochman M, Abberbock J, Barmada M, Bauer E, Brand R, Kennard E, LaRusch J, O'Connell M, Stello K, Slivka A, Talluri J, Tang G, Whitcomb D, Wisniewski S, Yadav D, Burton F, AlKaade S, DiSario J, Sandhu B, Money M, Steinberg W. Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium. Pancreatology 2022, 22: 1091-1098. PMID: 36404201, PMCID: PMC10122210, DOI: 10.1016/j.pan.2022.10.004.Peer-Reviewed Original ResearchConceptsDiagnosis of CPAcute pancreatitisChronic pancreatitisCP diagnosisAP patientsAssociation of APNorth American Pancreatitis StudiesMajority of patientsMultivariable logistic regressionDisease-related factorsNorth American cohortClinical acute pancreatitisAP episodeAbdominal painSecondary preventionMultivariable analysisExocrine insufficiencyPancreatic atrophyMore episodesUS CentersWhite raceLower oddsPatientsAmerican cohortPancreatitisPancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression
Fu D, Blobner B, Greer P, Lafyatis R, Bellin M, Whitcomb D, Study P, Bellin M, Beilman G, Study G, Brand R, Ohlsen C, Saloman J, Whitcomb D, Park H, Lee K, Paniccia A, Zureikat A, Group N, Alkaade S, Amann S, Anderson M, Banks P, Conwell D, Cote G, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Papachristou G, Romagnuolo J, Sandhu B, Sherman S, Singh V, Slivka A, Wilcox C, Yadav D. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression. Gastroenterology 2022, 164: 289-292.e4. PMID: 36191639, PMCID: PMC9892203, DOI: 10.1053/j.gastro.2022.09.036.Peer-Reviewed Original ResearchPost-liver transplantation bile leaks and strictures
Muniraj T. Post-liver transplantation bile leaks and strictures. Gastrointestinal Endoscopy 2022, 95: 1233-1237. PMID: 35124073, DOI: 10.1016/j.gie.2022.01.021.Peer-Reviewed Original Research
2021
Novel 15-mm-long lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic fluid collections located ≥10 mm from the luminal wall
Zhang LY, Kunda R, Aerts M, Messaoudi N, Pawa R, Pawa S, Robles-Medranda C, Oleas R, Al-Haddad MA, Obaitan I, Muniraj T, Fabbri C, Binda C, Anderloni A, Tarantino I, Bejjani M, Ghandour B, Singh V, Khashab MA. Novel 15-mm-long lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic fluid collections located ≥10 mm from the luminal wall. Endoscopy 2021, 54: 706-711. PMID: 34905796, DOI: 10.1055/a-1682-7095.Peer-Reviewed Original ResearchConceptsDrainage of PFCsLumen-apposing metal stentsPancreatic fluid collectionsFluid collectionClinical successLuminal wallEndoscopic ultrasound-guided drainageUltrasound-guided drainageEUS-guided drainageLumen-apposing metalPrimary outcomeSecondary outcomesMulticenter studyTechnical successDuodenal wallEndoscopic ultrasoundMaximal diameterMetal stentsLAMS placementComplicationsPatientsRecurrenceOutcomesDrainagePresent outcomesAutoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study
Yadav D, Whitcomb D, Tang G, Slivka A, Bellin M, Consortium N, AlKaade S, Amann S, Anderson M, Banks P, Conwell D, Brand R, Cote G, Romagnuolo J, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Sandhu B, Sherman S, Singh V, Wilcox C. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study. Clinical Gastroenterology And Hepatology 2021, 21: 226-228.e1. PMID: 34793964, DOI: 10.1016/j.cgh.2021.11.011.Peer-Reviewed Original ResearchConceptsChronic pancreatitisCytokine-induced beta-cell dysfunctionPancreatogenic diabetes mellitusPrimary pathophysiologic defectType 3c diabetesSubset of patientsBeta-cell dysfunctionRecurrent AcuteGlucose intoleranceDiabetes mellitusPathophysiologic defectsFibrotic changesInsulin deficiencyCell dysfunctionExocrine pancreasPilot studyPancreatitisMellitusAcuteDiabetesInflammationPatientsDysfunctionInjuryPancreasGallbladder Cryoablation: Other Endoscopic Options for High-Risk Patients with Cholecystitis
Jones J, Aslanian HR, Muniraj T. Gallbladder Cryoablation: Other Endoscopic Options for High-Risk Patients with Cholecystitis. The American Journal Of Medicine 2021, 134: e565. PMID: 34799010, DOI: 10.1016/j.amjmed.2021.06.006.Peer-Reviewed Original ResearchFully covered metal biliary stents: A review of the literature
Lam R, Muniraj T. Fully covered metal biliary stents: A review of the literature. World Journal Of Gastroenterology 2021, 27: 6357-6373. PMID: 34720527, PMCID: PMC8517778, DOI: 10.3748/wjg.v27.i38.6357.Peer-Reviewed Original ResearchPain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain
Dunbar EK, Greer PJ, Amann ST, Alkaade S, Banks P, Brand R, Conwell DL, Forsmark CE, Gardner TB, Guda NM, Lewis MD, Machicado JD, Muniraj T, Papachristou GI, Romagnuolo J, Sandhu BS, Sherman S, Slivka A, Wilcox CM, Yadav D, Whitcomb DC, Consortium F. Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain. The American Journal Of Gastroenterology 2021, 116: 2128-2136. PMID: 34236339, PMCID: PMC8531869, DOI: 10.14309/ajg.0000000000001366.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderChronic pancreatitisSevere painPain experienceThird of patientsPain management strategiesIdentification of patientsAbsence of painInflammatory syndromePain patternsCP patientsPain categoriesPain locusStudy cohortAcute pancreatitisAdrenal axisCP subjectsPainGenetic predispositionPatientsPsychiatric conditionsGenetic risk lociPTSD riskPancreatitisStress disorderResection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.Peer-Reviewed Original ResearchConceptsIntra-ductal papillary mucinous neoplasmRecurrent acute pancreatitisPancreatic cystic neoplasmsCystic neoplasmsBD-IPMNAcute pancreatitisCause of pancreatitisRole of resectionMucinous cystic neoplasmPrevalence of malignancyPapillary mucinous neoplasmSerous cystic neoplasmsCross-sectional imagingMean episodesRAP patientsSurgical resectionCyst resectionMD-IPMNPrimary outcomeIPMN patientsRecurrent pancreatitisRetrospective studyCyst featuresGallstone aetiologyMucinous neoplasmsAGA Clinical Practice Guidelines on Intragastric Balloons in the Management of Obesity
Muniraj T, Day LW, Teigen LM, Ho EY, Sultan S, Davitkov P, Shah R, Murad MH. AGA Clinical Practice Guidelines on Intragastric Balloons in the Management of Obesity. Gastroenterology 2021, 160: 1799-1808. PMID: 33832655, DOI: 10.1053/j.gastro.2021.03.003.Peer-Reviewed Original ResearchHealthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy
McCarty TR, Chouairi F, Hathorn KE, Sharma P, Muniraj T, Thompson CC. Healthcare Disparities in the Management of Acute Cholecystitis: Impact of Race, Gender, and Socioeconomic Factors on Cholecystectomy vs Percutaneous Cholecystostomy. Journal Of Gastrointestinal Surgery 2021, 25: 880-886. PMID: 33629232, DOI: 10.1007/s11605-021-04959-6.Peer-Reviewed Original ResearchConceptsLength of stayCharlson Comorbidity IndexPercutaneous cholecystostomyAcute cholecystitisRace/ethnicityU.S. Nationwide Inpatient Sample (NIS) databaseNationwide Inpatient Sample databaseAsian race/ethnicityHealthcare-related factorsHigher CCI scoresMedicare payer statusGood surgical candidatesMajority of patientsMultivariable logistic regressionUrban hospital locationUrban teaching hospitalSocioeconomic factorsCCI scoreComorbidity indexSurgical candidatesPayer statusMale genderHospital costsTeaching hospitalTreatment strategiesEndoscopic Removal of Ingested Wire Bristle from the Pancreas
Lerner BA, Aslanian HR, Muniraj T. Endoscopic Removal of Ingested Wire Bristle from the Pancreas. Clinical Gastroenterology And Hepatology 2021, 20: e649-e650. PMID: 33609785, PMCID: PMC8368074, DOI: 10.1016/j.cgh.2021.02.022.Peer-Reviewed Case Reports and Technical NotesEvaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis
Chouairi F, McCarty TR, Hathorn KE, Sharma P, Aslanian HR, Jamidar PA, Thompson CC, Muniraj T. Evaluation of socioeconomic and healthcare disparities on same admission cholecystectomy after endoscopic retrograde cholangiopancreatography among patients with acute gallstone pancreatitis. Surgical Endoscopy 2021, 36: 274-281. PMID: 33481109, DOI: 10.1007/s00464-020-08272-2.Peer-Reviewed Original ResearchConceptsSame-admission cholecystectomyAcute gallstone pancreatitisEndoscopic retrograde cholangiopancreatographyCharlson Comorbidity IndexGallstone pancreatitisRetrograde cholangiopancreatographyU.S. Nationwide Inpatient Sample (NIS) databaseHigher Charlson comorbidity indexNationwide Inpatient Sample databaseMedicare payer statusUrban-teaching hospitalsMajority of patientsMultivariable logistic regressionRace/ethnicitySocio-demographic factorsHospital mortalityComorbidity indexHospital stayPayer statusSurgical managementHospitalization costsResultsA totalBlack raceTreatment strategiesFemale genderGallbladder Disorders: A Comprehensive Review
Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T. Gallbladder Disorders: A Comprehensive Review. Disease-a-Month 2021, 67: 101130. PMID: 33478678, DOI: 10.1016/j.disamonth.2021.101130.Peer-Reviewed Original Research
2020
Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance
Chhoda A, Yousaf MN, Madhani K, Aslanian H, Jamidar PA, Suarez AL, Salem R, Muniraj T, Kunstman J, Farrell JJ. Comorbidities Drive the Majority of Overall Mortality in Low-Risk Mucinous Pancreatic Cysts Under Surveillance. Clinical Gastroenterology And Hepatology 2020, 20: 631-640.e1. PMID: 33309984, DOI: 10.1016/j.cgh.2020.12.008.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexHigh-risk stigmataMucinous pancreatic cystsOverall mortalityWorrisome featuresPancreatic cystsComorbidity burdenAge-adjusted Charlson comorbidity indexKaplan-Meir survival analysisLow-risk cystsSingle-center studyHigher overall mortalityElectronic medical recordsComorbidity indexProspective surveillanceCenter studyMortality outcomesMedical recordsMucinous cystsPatient outcomesSerial imagingSurveillance populationCohort stratificationSurvival analysisAbstractText