2024
TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing
Loeb S, Keith S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Hartman R, Brown L, Pieczonka C, Gomella L, Kelly W, Lallas C, Handley N, Mille P, Mark J, Brown G, Chopra S, McClellan A, Wise D, Hollifield L, Giri V. TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing. JCO Precision Oncology 2024, 8: e2300552. PMID: 38452310, PMCID: PMC10939575, DOI: 10.1200/po.23.00552.Peer-Reviewed Original ResearchConceptsGermline genetic testingDecisional conflictGenetic counselingProstate cancerPatient-drivenShortage of genetic counselorsKnowledge of cancer geneticsHereditary cancer riskReduce decisional conflictDecisional Conflict ScalePrimary outcome dataMixed-effects regression modelsDiverse patient populationsGenetic servicesClinical trial eligibilityGenetic counselorsGenetics educationPatient experienceCancer riskGermline testingAnalytical data setsCancer geneticsGermline evaluationConflict ScaleGenetic testing
2023
Technology-enhanced acceleration of germline evaluation for therapy (TARGET): Results of a randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing.
Giri V, Keith S, Cheng H, Leader A, Gross L, Sanchez Nolasco T, Byrne N, Hartman R, Brown L, Pieczonka C, Gomella L, Kelly W, Lallas C, Handley N, Mille P, Mark J, Brown G, Chopra S, McClellan A, Loeb S. Technology-enhanced acceleration of germline evaluation for therapy (TARGET): Results of a randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Journal Of Clinical Oncology 2023, 41: 10598-10598. DOI: 10.1200/jco.2023.41.16_suppl.10598.Peer-Reviewed Original ResearchDecisional conflictGenetic testingPre-test genetic counselingGermline testingGenetic counselingProstate cancerRandomized non-inferiority trialHereditary cancer risk assessmentGermline genetic testingClinical trial eligibilityNon-inferiority trialProstate Cancer FoundationProstate cancer managementCancer genetic testingDecision Conflict ScaleCancer risk assessmentGermline evaluationTrial eligibilityPrimary endpointMean ageStudy protocolCancer managementGenetics educationAnalysis of covarianceCancer Foundation
2022
Assessment of Concurrent Personal and Family History of Hematologic Malignancies in Patients Referred for Genetic Counseling at Thomas Jefferson University Hospital (TJUH), Sidney Kimmel Cancer Center (SKCC) from 2014-2021
Halloran M, Keiffer G, Giri V, Gross L, Wilde L, Palmisiano N, Porcu P, Kasner M. Assessment of Concurrent Personal and Family History of Hematologic Malignancies in Patients Referred for Genetic Counseling at Thomas Jefferson University Hospital (TJUH), Sidney Kimmel Cancer Center (SKCC) from 2014-2021. Blood 2022, 140: 11466-11467. DOI: 10.1182/blood-2022-165510.Peer-Reviewed Original ResearchTechnology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing
Loeb S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Wise D, Hollifield L, Brown L, Slater E, Pieczonka C, Gomella L, Kelly W, Trabulsi E, Handley N, Lallas C, Chandrasekar T, Mille P, Mann M, Mark J, Brown G, Chopra S, Wasserman J, Phillips J, Somers P, Giri V. Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Contemporary Clinical Trials 2022, 119: 106821. PMID: 35710085, DOI: 10.1016/j.cct.2022.106821.Peer-Reviewed Original ResearchConceptsKey patient-reported outcomesGermline testingPatient-reported outcomesProstate cancerGenetic counselingCollaborative care strategiesProstate cancer careTwo-armed randomizedProstate Cancer FoundationEducation/counselingGermline evaluationGOV IDENTIFIERPrimary outcomeSecondary outcomesStudy armsTarget enrollmentAshkenazi Jewish ancestryCancer careFamily historyTumor featuresCancer FoundationCare strategiesDecisional conflictUS sitesPractice settingsPatient-reported outcomes among males undergoing prostate cancer germline testing: Interim results from the Prostate Cancer Genetic Risk, Experience, and Support Study (PROGRESS) Registry.
Giri V, Hartman R, Gross L, Keith S. Patient-reported outcomes among males undergoing prostate cancer germline testing: Interim results from the Prostate Cancer Genetic Risk, Experience, and Support Study (PROGRESS) Registry. Journal Of Clinical Oncology 2022, 40: 10595-10595. DOI: 10.1200/jco.2022.40.16_suppl.10595.Peer-Reviewed Original ResearchPatient-reported outcomesGermline testingGenetic testingPROGRESS registryDecisional conflictNon-Hispanic/LatinoDiagnosis of PCaCancer genetic riskGenetic counselingCancer geneticsPatient experience informationStudy registryGleason scoreRegistry participantsFamily historyRegistryGenetic resultsAfrican American malesCategorical variablesGenetic riskSAS 9.4Traditional genetic counselingDemographic informationGenetic mutationsMenGermline Variant Spectrum Among African American Men Undergoing Prostate Cancer Germline Testing: Need for Equity in Genetic Testing
Giri V, Hartman R, Pritzlaff M, Horton C, Keith S. Germline Variant Spectrum Among African American Men Undergoing Prostate Cancer Germline Testing: Need for Equity in Genetic Testing. JCO Precision Oncology 2022, 6: e2200234. PMID: 35666082, PMCID: PMC9200399, DOI: 10.1200/po.22.00234.Peer-Reviewed Original ResearchConceptsGermline testingAA menWhite menHereditary cancer assessmentStandard clinical testingCohort of menAfrican American menGermline evaluationMultivariable analysisClinical managementBorderline associationLP variantsVariant statusClinical testingGermline analysisPanel testingRate of variantsCare deliveryVariant spectrumGenetic testingCancer assessmentUncertain significanceDNA repair genesGenetic counselingAmerican menVirtual genetics board for enhancing knowledge and practice of prostate cancer genetic testing: The ENGAGEMENT study.
Giri V, Gross L, Cheng H, Russo J, Paller C, Johnson J, Weg E, Loeb S. Virtual genetics board for enhancing knowledge and practice of prostate cancer genetic testing: The ENGAGEMENT study. Journal Of Clinical Oncology 2022, 40: 184-184. DOI: 10.1200/jco.2022.40.6_suppl.184.Peer-Reviewed Original ResearchMetastatic prostate cancerProstate cancerGermline testingGenetic counselingRisk of PCaEarly-stage prostate cancerBaseline surveyHigh-risk diseaseStandard of careCancer genetic testingCancer genetics knowledgeMedical oncologistsMedical oncologyClinical trial managementClinical trialsNurse practitionersCancer managementAcademic centersFavorable responseCase discussionRadiation oncologistsPCa screeningKnowledge scoreGenetic testingPractice settings
2021
Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs
Russo J, McDougall C, Bowler N, Shimada A, Gross L, Hyatt C, Kelly W, Calvaresi A, Handley N, Hirsch I, Izes J, Lallas C, Mann M, Mark J, Mille P, Preate D, Trabulsi E, Tsang M, Chandrasekar T, Weiner P, Gomella L, Giri V. Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs. JCO Precision Oncology 2021, 5: 1377-1386. PMID: 34589662, PMCID: PMC8462590, DOI: 10.1200/po.21.00238.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerGenetic counselingDecisional conflictComparable patient-reported outcomesHereditary cancer assessmentPatient-reported outcomesCancer genetics knowledgePCa diagnosisPractice settingsPrecision careCancer assessmentInformed consentCategorical variablesSubstantial proportionGenetic knowledgeSignificant differencesContinuous variablesHigh rateMenPractice needsDescriptive statisticsProstate oncologyOutcomesCounselingBarriers and facilitators of germline genetic evaluation for prostate cancer
Loeb S, Li R, Nolasco T, Byrne N, Cheng H, Becker D, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. The Prostate 2021, 81: 754-764. PMID: 34057231, DOI: 10.1002/pros.24172.Peer-Reviewed Original ResearchConceptsCoordination of careProstate cancerChronic Diseases frameworkGuideline-concordant careGermline testingMedical oncologistsPatient factorsPhysicians' knowledgePhysician educationRadiation oncologistsPractice settingsDisease frameworkThematic saturationGenetic counselingGenetic evaluationCareOncologistsRecent dataCancerConstant comparative methodInterview guidePhysiciansNumerous barriersQualitative studyInterview transcriptsBarriers and facilitators of germline genetic evaluation for prostate cancer.
Loeb S, Li R, Sanchez Nolasco T, Byrne N, Cheng H, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. Journal Of Clinical Oncology 2021, 39: 28-28. DOI: 10.1200/jco.2021.39.6_suppl.28.Peer-Reviewed Original ResearchCoordination of careProstate cancerGenetic testingChronic Diseases frameworkGuideline-concordant careGermline genetic testingMetastatic prostate cancerGenetic counselingGermline testingLocalized diseasePatient factorsMedical oncologistsTherapeutic optionsCancer screeningPhysicians' knowledgeCurrent guidelinesPhysician educationRecent approvalRadiation oncologistsPractice settingsCancerDisease frameworkThematic saturationProstate Cancer GeneticsGenetic evaluation
2020
Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC.
Szymaniak BM, Facchini LA, Giri VN, Antonarakis ES, Beer TM, Carlo MI, Danila DC, Dhawan M, George D, Graff JN, Gupta S, Heath E, Higano CS, Liu G, Molina AM, Paller CJ, Patnaik A, Petrylak DP, Reichert Z, Rettig MB, Ryan CJ, Taplin ME, Vinson J, Whang YE, Morgans AK, Cheng HH, McKay RR. Practical Considerations and Challenges for Germline Genetic Testing in Patients With Prostate Cancer: Recommendations From the Germline Genetics Working Group of the PCCTC. JCO Oncology Practice 2020, 16: 811-819. PMID: 32986533, PMCID: PMC7735040, DOI: 10.1200/op.20.00431.Peer-Reviewed Original ResearchConceptsGermline genetic testingProstate cancerGenetic testingNumber of patientsCritical unmet needCurrent guidelinesTesting deliveryPatientsUnmet needPrecision oncologyGenomic testingGenetic counselingGenetics providersGenetic servicesClinical workflowCancerOncologyLimited accessWorking GroupGuidelinesStandardized systemProvidersTestingClinicKnowledge and practice regarding prostate cancer germline testing among urologists: Gaps to address for optimal implementation✰,✰✰
Loeb S, Byrne N, Walter D, Makarov D, Wise D, Becker D, Giri V. Knowledge and practice regarding prostate cancer germline testing among urologists: Gaps to address for optimal implementation✰,✰✰. Cancer Treatment And Research Communications 2020, 25: 100212. PMID: 33091732, DOI: 10.1016/j.ctarc.2020.100212.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerUrologic practicePCa family historyLocalized prostate cancerMetastatic prostate cancerFamily history criteriaDiverse practice settingsHypothetical case scenariosGermline evaluationU.S. urologistsCancer screeningOvarian cancerPractice patternsFamily historySpecific histologicPCa prognosisNational guidelinesAmerican Urological Association sectionYounger agePractice settingsTesting guidelinesHistory criteriaUrologistsGenetic counselingVideo vs. in-person genetic counseling for men considering germline prostate cancer testing: A patient-choice study.
Giri V, Bowler N, Hegarty S, Gross L, Hyatt C, Kelly W, Gomella L. Video vs. in-person genetic counseling for men considering germline prostate cancer testing: A patient-choice study. Journal Of Clinical Oncology 2020, 38: 1577-1577. DOI: 10.1200/jco.2020.38.15_suppl.1577.Peer-Reviewed Original ResearchCancer genetics knowledgeGermline testingPerson genetic counselingProstate cancerGenetic counselingBaseline anxietyDecisional conflictPatient-reported outcomesAfrican American raceProstate cancer testingHigh baseline anxietyLow educational levelFisher's exactFamily historyPCa diagnosisCancer testingAmerican raceCategorical variablesFirst cohortPathogenic mutationsLow knowledgeSAS 9.4Chi-squaredSubstantial proportionMenExploring African American males' attitudes towards genetic testing for prostate cancer risk.
Leader A, Fortune T, Weddington P, Crumpler N, Giri V. Exploring African American males' attitudes towards genetic testing for prostate cancer risk. Journal Of Clinical Oncology 2020, 38: e13552-e13552. DOI: 10.1200/jco.2020.38.15_suppl.e13552.Peer-Reviewed Original ResearchFamily historyGenetic testingAA malesAA menHigher prostate cancer incidencePrimary care visitsProstate cancer incidenceGenetic counselingImportant risk factorProstate cancer riskHealth history informationFocus groupsFamily health historyCare visitsMean ageCancer incidenceRisk factorsCancer riskMortality rateHealth historyLow-resource neighborhoodsCare limitationsInformed consentMost menAfrican American malesPhysical activity assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment.
Giri V, Milliron B, Sinclair E, Obeid E, Smaltz C, Butryn M, Bruneau M. Physical activity assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment. Journal Of Clinical Oncology 2020, 38: 360-360. DOI: 10.1200/jco.2020.38.6_suppl.360.Peer-Reviewed Original ResearchBody mass indexProstate cancerGenetic testingGenetic counselingPA guidelinesVigorous PAHealthy lifestyleLower body mass indexFuture lifestyle interventionsCurrent PA guidelinesOverweight/obesePhysical activity guidelinesSignificant predictorsLogistic regression analysisPhysical activity assessmentFrequency of PATeachable momentStrength-based activitiesLifestyle interventionPA adherencePCa aggressivenessActivity guidelinesMass indexPCa statusLifestyle questionnaire
2019
Diet assessment among men undergoing genetic counseling and genetic testing for inherited prostate cancer: Exploring a teachable moment to support diet intervention
Milliron B, Bruneau M, Obeid E, Gross L, Bealin L, Smaltz C, Giri V. Diet assessment among men undergoing genetic counseling and genetic testing for inherited prostate cancer: Exploring a teachable moment to support diet intervention. The Prostate 2019, 79: 778-783. PMID: 30905089, PMCID: PMC8283914, DOI: 10.1002/pros.23783.Peer-Reviewed Original ResearchConceptsBody mass indexProstate cancerGenetic testingDiet interventionGenetic counselingStructured food frequency questionnaireCancer prevention goalsInherited prostate cancerFood frequency questionnaireUSDA recommendationsNumber of servingsHealthy lifestyle promotionLack of adherenceTeachable momentComplete survey dataFrequency questionnaireMass indexBMI classificationLess vegetablesPCa statusFamily historyNutrition interventionsDiet recommendationsCancer survivorshipCancer risk
2018
Evolving Intersection Between Inherited Cancer Genetics and Therapeutic Clinical Trials in Prostate Cancer: A White Paper From the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium.
Carlo M, Giri V, Paller C, Abida W, Alumkal J, Beer T, Beltran H, George D, Heath E, Higano C, McKay R, Morgans A, Patnaik A, Ryan C, Schaeffer E, Stadler W, Taplin M, Kauff N, Vinson J, Antonarakis E, Cheng H. Evolving Intersection Between Inherited Cancer Genetics and Therapeutic Clinical Trials in Prostate Cancer: A White Paper From the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium. JCO Precision Oncology 2018, 2018: 1-14. PMID: 30761386, PMCID: PMC6370313, DOI: 10.1200/po.18.00060.Peer-Reviewed Original ResearchGermline genetic testingProstate cancerGenetic testingAdvanced diseaseClinical trialsTreatment selectionProstate Cancer Clinical Trials ConsortiumClinical trial eligibility determinationCascade testingClinical Trials ConsortiumTherapeutic clinical trialsGenetic counselingClinical trial purposesTumor genomic profilingPost-test genetic counselingCancer risk assessmentDNA damage repair genesAppropriate genetic counselingTreatment response predictionWorking GroupClinical benefitPrompt testingCancer screeningGenetic testing practicesTreatment decisionsNutrition assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment.
Giri V, Bruneau M, Obeid E, Smaltz C, Milliron B. Nutrition assessment among men undergoing genetic counseling for inherited prostate cancer: A teachable moment. Journal Of Clinical Oncology 2018, 36: 1519-1519. DOI: 10.1200/jco.2018.36.15_suppl.1519.Peer-Reviewed Original ResearchUnderstanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling
Giri V, Obeid E, Hegarty S, Gross L, Bealin L, Hyatt C, Fang C, Leader A. Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling. The Prostate 2018, 78: 879-888. PMID: 29655297, PMCID: PMC6047906, DOI: 10.1002/pros.23535.Peer-Reviewed Original ResearchConceptsInherited prostate cancerProstate cancerGenetic counselingGenetic testingMultivariable linear regressionFamily history dataPre-test genetic counselingHigh baseline knowledgeSyndrome criteriaGermline testingMultivariable analysisMultigene testingMedical recordsFamily historyCancer riskSubset of malesMcNemar testUncertain significanceGEM participantsHigher knowledgeMeasures of knowledgeGenetic resultsMenGT resultsBaseline knowledge
2017
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017
Giri VN, Knudsen KE, Kelly WK, Abida W, Andriole GL, Bangma CH, Bekelman JE, Benson MC, Blanco A, Burnett A, Catalona WJ, Cooney KA, Cooperberg M, Crawford DE, Den RB, Dicker AP, Eggener S, Fleshner N, Freedman ML, Hamdy FC, Hoffman-Censits J, Hurwitz MD, Hyatt C, Isaacs WB, Kane CJ, Kantoff P, Karnes RJ, Karsh LI, Klein EA, Lin DW, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann MJ, Mark JR, McCue PA, Miner MM, Morgan T, Moul JW, Myers RE, Nielsen SM, Obeid E, Pavlovich CP, Peiper SC, Penson DF, Petrylak D, Pettaway CA, Pilarski R, Pinto PA, Poage W, Raj GV, Rebbeck TR, Robson ME, Rosenberg MT, Sandler H, Sartor O, Schaeffer E, Schwartz GF, Shahin MS, Shore ND, Shuch B, Soule HR, Tomlins SA, Trabulsi EJ, Uzzo R, Vander Griend DJ, Walsh PC, Weil CJ, Wender R, Gomella LG. Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. Journal Of Clinical Oncology 2017, 36: jco.2017.74.117. PMID: 29236593, PMCID: PMC6075860, DOI: 10.1200/jco.2017.74.1173.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProstate cancerGenetic testingMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerAggressive prostate cancerProstate cancer riskGenetic counselingMultidisciplinary consensus statementDNA mismatch repair genesExpert consensus conferenceFamilial prostate cancerHereditary prostate cancerClinical genetic testingMismatch repair genesMetastatic settingPCa managementLynch syndromeOvarian cancerBRCA2 mutationsConsensus statementFamily historyCancer riskHeterogeneous diseaseConsensus conferenceComprehensive genetic evaluation