Featured Publications
Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention
Seibert T, Garraway I, Plym A, Mahal B, Giri V, Jacobs M, Cheng H, Loeb S, Helfand B, Eeles R, Morgan T. Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention. European Urology 2023, 83: 241-248. PMID: 36609003, DOI: 10.1016/j.eururo.2022.12.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTimes higher riskGenetic risk scoreHigh genetic risk scoreLethal prostate cancerProstate cancerHigh genetic riskHigh riskRare pathogenic mutationsHealthy lifestyleEarly detectionPCa riskRisk predictionHigh-grade prostate cancerGenetic riskAggressive prostate cancerProstate cancer riskGenetic risk assessmentDNA damage repair genesGenetic risk predictionPCa mortalityAggressive diseaseLeading causeFamily historyCancer riskElevated risk
2020
The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer
Lynch S, Handorf E, Sorice K, Blackman E, Bealin L, Giri V, Obeid E, Ragin C, Daly M. The effect of neighborhood social environment on prostate cancer development in black and white men at high risk for prostate cancer. PLOS ONE 2020, 15: e0237332. PMID: 32790761, PMCID: PMC7425919, DOI: 10.1371/journal.pone.0237332.Peer-Reviewed Original ResearchConceptsProstate-specific antigenPCa family historyHigh-risk menProbability of PCaFamily historyPCa diagnosisRisk menWhite menDigital rectal examEarly Detection ProgramClinical risk assessmentProstate cancer disparitiesProstate cancer developmentPatient risk assessmentNeighborhood socioeconomic factorsPatient-level modelsCox regressionRectal examBaseline ageCancer disparitiesPatient variablesProstate cancerHigh riskNeighborhood social environmentClinical relevance
2017
Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation
Giri V, Obeid E, Gross L, Bealin L, Hyatt C, Hegarty S, Montgomery S, Forman A, Bingler R, Kelly W, Dicker A, Winheld S, Trabulsi E, Chen D, Lallas C, Allen B, Daly M, Gomella L. Inherited Mutations in Men Undergoing Multigene Panel Testing for Prostate Cancer: Emerging Implications for Personalized Prostate Cancer Genetic Evaluation. JCO Precision Oncology 2017, 1: 1-17. PMID: 34164591, PMCID: PMC8210976, DOI: 10.1200/po.16.00039.Peer-Reviewed Original ResearchFamily historyGenetic counselingMultigene testingEligibility criteriaPrecision therapyFH dataDNA repair genesReferral of menEarly-stage diseaseMultigene panel testingOvarian cancer syndromeStrong family historyCancer genetic evaluationStage/gradeRepair genesDetailed family historyPersonalized genetic counselingProstate cancer predispositionMetastatic diseaseCancer screeningMedical recordsProstate cancerBreast cancerMutation carriersHigh risk
2016
Effects of a randomized trial comparing standard and enhanced counseling for men at high risk of prostate cancer as a function of race and monitoring style
Roussi P, Miller S, Giri V, Obeid E, Wen K, Tagai E, Scarpato J, Gross L, Roy G. Effects of a randomized trial comparing standard and enhanced counseling for men at high risk of prostate cancer as a function of race and monitoring style. Journal Of Health Psychology 2016, 23: 1800-1809. PMID: 28810355, PMCID: PMC5561513, DOI: 10.1177/1359105316671188.Peer-Reviewed Original ResearchConceptsProstate cancer screeningHigh-risk menCancer screeningProstate Cancer Risk Assessment ProgramRoutine prostate cancer screeningCancer Risk Assessment ProgramHealth education sessionsCounseling visitsEnhanced counselingProstate cancerHigh riskEducation sessionsRisk assessment programPsychosocial impactCounseling conditionMenSelf-selected sampleFunction of raceSignificant subsetRiskIntrusive ideationInterventionCounselingScreeningMonitoring style
2014
Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
Bancroft E, Page E, Castro E, Lilja H, Vickers A, Sjoberg D, Assel M, Foster C, Mitchell G, Drew K, Mæhle L, Axcrona K, Evans D, Bulman B, Eccles D, McBride D, van Asperen C, Vasen H, Kiemeney L, Ringelberg J, Cybulski C, Wokolorczyk D, Selkirk C, Hulick P, Bojesen A, Skytte A, Lam J, Taylor L, Oldenburg R, Cremers R, Verhaegh G, van Zelst-Stams W, Oosterwijk J, Blanco I, Salinas M, Cook J, Rosario D, Buys S, Conner T, Ausems M, Ong K, Hoffman J, Domchek S, Powers J, Teixeira M, Maia S, Foulkes W, Taherian N, Ruijs M, Enden A, Izatt L, Davidson R, Adank M, Walker L, Schmutzler R, Tucker K, Kirk J, Hodgson S, Harris M, Douglas F, Lindeman G, Zgajnar J, Tischkowitz M, Clowes V, Susman R, Ramón y Cajal T, Patcher N, Gadea N, Spigelman A, van Os T, Liljegren A, Side L, Brewer C, Brady A, Donaldson A, Stefansdottir V, Friedman E, Chen-Shtoyerman R, Amor D, Copakova L, Barwell J, Giri V, Murthy V, Nicolai N, Teo S, Greenhalgh L, Strom S, Henderson A, McGrath J, Gallagher D, Aaronson N, Ardern-Jones A, Bangma C, Dearnaley D, Costello P, Eyfjord J, Rothwell J, Falconer A, Gronberg H, Hamdy F, Johannsson O, Khoo V, Kote-Jarai Z, Lubinski J, Axcrona U, Melia J, McKinley J, Mitra A, Moynihan C, Rennert G, Suri M, Wilson P, Killick E, Collaborators T, Moss S, Eeles R. Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study. European Urology 2014, 66: 489-499. PMID: 24484606, PMCID: PMC4105321, DOI: 10.1016/j.eururo.2014.01.003.Peer-Reviewed Original ResearchConceptsPositive predictive valueHigh-risk diseaseBRCA2 mutation carriersProstate cancerTargeted prostate cancerMutation carriersBRCA1/2 mutationsHigh riskProstate-specific antigen (PSA) testingProstate cancer screeningScreening resultsGermline BRCA1/2 mutationsFisher's exact testInitial screening roundGermline genetic markersIdentification of tumorsBreast cancer 1Germline genetic risk variantsBreast cancer 2PCa incidencePSA levelsAntigen testingTumor characteristicsAggressive diseaseBRCA2 carriers
2009
Prostate Cancer Early Detection Program Recruitment Methods and Show Rates in Men at High Risk
Giri V, Coups E, Ruth K, Goplerud J, Raysor S, Kim T, Bagden L, Mastalski K, Zakrzewski D, Leimkuhler S, Watkins-Bruner D. Prostate Cancer Early Detection Program Recruitment Methods and Show Rates in Men at High Risk. Journal Of Urology 2009, 182: 2212-2218. PMID: 19758657, PMCID: PMC2760660, DOI: 10.1016/j.juro.2009.07.021.Peer-Reviewed Original ResearchConceptsHigh riskProstate cancerFamily historyProstate cancer screening studyProstate cancer risk assessmentProstate Cancer Risk Assessment ProgramProstate cancer family historyRecruitment methodsShow ratesCancer Risk Assessment ProgramProstate cancer screeningCancer screening studyEarly Detection ProgramCancer family historyLow socioeconomic statusBlack menCancer risk assessmentMen 35Cancer screeningLow presentation ratesBRCA1/2 mutationsRisk assessment programProgram visitsMore menParticipant demographicsDairy intake and 1,25-dihydroxyvitamin D levels in men at high risk for prostate cancer
Tseng M, Giri V, Watkins-Bruner D, Giovannucci E. Dairy intake and 1,25-dihydroxyvitamin D levels in men at high risk for prostate cancer. Cancer Causes & Control 2009, 20: 1947-1954. PMID: 19578936, PMCID: PMC2895954, DOI: 10.1007/s10552-009-9389-9.Peer-Reviewed Original ResearchConceptsProstate cancerAssociation of dairyVitamin D intakeDihydroxyvitamin D levelsVitamin D statusProstate cancer riskHealth history questionnaireHigh-risk programD intakeD statusCalcium intakeHydroxyvitamin DAlcohol intakeD levelsDairy calciumDairy intakeInverse associationFood intakeCancer riskHigh riskConclusionOur findingsHistory questionnaireEnergy intakeMultivariate linear regressionIntake
2007
Prostate Cancer Risk Assessment Program: A 10-Year Update of Cancer Detection
Giri V, Beebe-Dimmer J, Buyyounouski M, Konski A, Feigenberg S, Uzzo R, Hanks G, Godwin A, Chen D, Gordon R, Cescon T, Raysor S, Watkins-Bruner D. Prostate Cancer Risk Assessment Program: A 10-Year Update of Cancer Detection. Journal Of Urology 2007, 178: 1920-1924. PMID: 17868726, DOI: 10.1016/j.juro.2007.07.010.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramCancer Risk Assessment ProgramProstate-specific antigenProstate cancerSpecific antigenHigh riskRisk assessment programFamily historyNormal digital rectal examinationFree prostate-specific antigenLongitudinal screening programUnderwent prostate biopsyDigital rectal examinationProstate cancer incidenceGleason score 7Prostate cancer featuresGleason score 6Majority of cancersCancer detectionParticipants 19Biopsy criteriaLocal therapyRectal examinationProstate biopsyCancer incidence