Featured Publications
Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention
Seibert T, Garraway I, Plym A, Mahal B, Giri V, Jacobs M, Cheng H, Loeb S, Helfand B, Eeles R, Morgan T. Genetic Risk Prediction for Prostate Cancer: Implications for Early Detection and Prevention. European Urology 2023, 83: 241-248. PMID: 36609003, DOI: 10.1016/j.eururo.2022.12.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTimes higher riskGenetic risk scoreHigh genetic risk scoreLethal prostate cancerProstate cancerHigh genetic riskHigh riskRare pathogenic mutationsHealthy lifestyleEarly detectionPCa riskRisk predictionHigh-grade prostate cancerGenetic riskAggressive prostate cancerProstate cancer riskGenetic risk assessmentDNA damage repair genesGenetic risk predictionPCa mortalityAggressive diseaseLeading causeFamily historyCancer riskElevated risk
2020
Exploring African American males' attitudes towards genetic testing for prostate cancer risk.
Leader A, Fortune T, Weddington P, Crumpler N, Giri V. Exploring African American males' attitudes towards genetic testing for prostate cancer risk. Journal Of Clinical Oncology 2020, 38: e13552-e13552. DOI: 10.1200/jco.2020.38.15_suppl.e13552.Peer-Reviewed Original ResearchFamily historyGenetic testingAA malesAA menHigher prostate cancer incidencePrimary care visitsProstate cancer incidenceGenetic counselingImportant risk factorProstate cancer riskHealth history informationFocus groupsFamily health historyCare visitsMean ageCancer incidenceRisk factorsCancer riskMortality rateHealth historyLow-resource neighborhoodsCare limitationsInformed consentMost menAfrican American malesHereditary Prostate Cancer
Giri V, Beebe-Dimmer J, Cooney K. Hereditary Prostate Cancer. 2020, 283-292. DOI: 10.1201/9781351187435-33.Peer-Reviewed Original ResearchHereditary prostate cancerProstate cancerCancer syndromesGenetic testing guidelinesMetastatic prostate cancerProstate cancer riskOvarian cancer syndromeHereditary cancer syndromesPrecision oncology studyClinical featuresLynch syndromeFatal cancerCancer riskGenetic predispositionHereditary breastCancerGenetic testingFamilial clusteringTesting guidelinesSyndromeGermline geneticsOncology studiesCancer susceptibilityGermline variationClinical application
2019
Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'.
Gomella L, Knudsen K, Giri V. Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'. Canadian Journal Of Urology 2019, 26: 1-4. PMID: 31629412.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInherited prostate cancerGenetic testingProstate cancerFirst International Consensus ConferenceKimmel Cancer CenterProstate cancer riskInternational Consensus ConferenceCancer ConsensusCancer CenterThomas Jefferson UniversityCancer riskConsensus meetingConsensus conferenceCancerFollowTesting
2018
The Frequency of CHEK2 variant p.Ile157Thr in Men with Prostate Cancer: Towards Expanded Genetic Testing
Agubokwu N, Giri V. The Frequency of CHEK2 variant p.Ile157Thr in Men with Prostate Cancer: Towards Expanded Genetic Testing. The FASEB Journal 2018, 32: 532.9-532.9. DOI: 10.1096/fasebj.2018.32.1_supplement.532.9.Peer-Reviewed Original Research
2017
Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017
Giri VN, Knudsen KE, Kelly WK, Abida W, Andriole GL, Bangma CH, Bekelman JE, Benson MC, Blanco A, Burnett A, Catalona WJ, Cooney KA, Cooperberg M, Crawford DE, Den RB, Dicker AP, Eggener S, Fleshner N, Freedman ML, Hamdy FC, Hoffman-Censits J, Hurwitz MD, Hyatt C, Isaacs WB, Kane CJ, Kantoff P, Karnes RJ, Karsh LI, Klein EA, Lin DW, Loughlin KR, Lu-Yao G, Malkowicz SB, Mann MJ, Mark JR, McCue PA, Miner MM, Morgan T, Moul JW, Myers RE, Nielsen SM, Obeid E, Pavlovich CP, Peiper SC, Penson DF, Petrylak D, Pettaway CA, Pilarski R, Pinto PA, Poage W, Raj GV, Rebbeck TR, Robson ME, Rosenberg MT, Sandler H, Sartor O, Schaeffer E, Schwartz GF, Shahin MS, Shore ND, Shuch B, Soule HR, Tomlins SA, Trabulsi EJ, Uzzo R, Vander Griend DJ, Walsh PC, Weil CJ, Wender R, Gomella LG. Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017. Journal Of Clinical Oncology 2017, 36: jco.2017.74.117. PMID: 29236593, PMCID: PMC6075860, DOI: 10.1200/jco.2017.74.1173.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProstate cancerGenetic testingMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerAggressive prostate cancerProstate cancer riskGenetic counselingMultidisciplinary consensus statementDNA mismatch repair genesExpert consensus conferenceFamilial prostate cancerHereditary prostate cancerClinical genetic testingMismatch repair genesMetastatic settingPCa managementLynch syndromeOvarian cancerBRCA2 mutationsConsensus statementFamily historyCancer riskHeterogeneous diseaseConsensus conferenceComprehensive genetic evaluation
2016
Familial prostate cancer
Giri V, Beebe-Dimmer J. Familial prostate cancer. Seminars In Oncology 2016, 43: 560-565. PMID: 27899188, PMCID: PMC6986340, DOI: 10.1053/j.seminoncol.2016.08.001.Peer-Reviewed Original ResearchConceptsFamilial prostate cancerProstate cancer riskProstate cancerHereditary prostate cancerBRCA2 mutationsFamily historyCancer riskNational Comprehensive Cancer Network guidelinesGenetic testingProstate cancer screeningFamily cancer historyProstate cancer patientsEarly-onset diseasePositive family historyFirst-degree relativesClustering of casesNetwork guidelinesColorectal cancerCancer historyCancer patientsCancer screeningCommon tumorsRisk factorsSurrogate markerOvarian cancer
2015
Interest in genomic SNP testing for prostate cancer risk: a pilot survey
Hall M, Ruth K, Chen D, Gross L, Giri V. Interest in genomic SNP testing for prostate cancer risk: a pilot survey. Hereditary Cancer In Clinical Practice 2015, 13: 11. PMID: 25874018, PMCID: PMC4396119, DOI: 10.1186/s13053-015-0032-3.Peer-Reviewed Original ResearchProstate cancer riskProstate Cancer Risk Assessment ProgramCancer riskHealth literacySNP testingCancer Risk Assessment ProgramSingle nucleotide polymorphismsHigher health literacyHigh-risk menHigh-risk statusNovel genomic testsPredictors of interestOne-time surveyUrology clinicProstate cancerMultivariable modelingClinical utilityPsychosocial factorsRisk assessment programGenomic testingGenomic testsUnsolicited findingsLow literacyRiskMen
2013
Prevalence of the HOXB13 G84E Mutation Among Unaffected Men with a Family History of Prostate Cancer
Handorf E, Crumpler N, Gross L, Giri V. Prevalence of the HOXB13 G84E Mutation Among Unaffected Men with a Family History of Prostate Cancer. Journal Of Genetic Counseling 2013, 23: 371-376. PMID: 24310616, PMCID: PMC4028414, DOI: 10.1007/s10897-013-9672-5.Peer-Reviewed Original ResearchConceptsHOXB13 G84E mutationProstate cancerG84E mutationFamily historyProstate cancer screening programsCancer screening programsProstate cancer screeningProstate cancer riskHigh-risk menMen ages 35HOXB13 G84ECancer screeningExact binomial confidence intervalsMutation carriersScreening programAge 35Cancer riskClinical utilityUnaffected menPrevalence estimatesGenetic testingPrevalenceCancerConfidence intervalsGenetic counseling
2009
Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high‐risk screening population
Kaplan D, Boorjian S, Ruth K, Egleston B, Chen D, Viterbo R, Uzzo R, Buyyounouski M, Raysor S, Giri V. Evaluation of the Prostate Cancer Prevention Trial Risk calculator in a high‐risk screening population. BJU International 2009, 105: 334-337. PMID: 19709072, PMCID: PMC2809782, DOI: 10.1111/j.1464-410x.2009.08793.x.Peer-Reviewed Original ResearchConceptsProstate Cancer Risk Assessment ProgramProstate Cancer Prevention Trial Risk CalculatorProstate cancer riskHigh-risk menProstate cancerPSA levelsRisk scoreFamily historyAfrican American menPCPT calculatorRisk calculatorCancer riskLower baseline prostate-specific antigen levelsBaseline prostate-specific antigen levelLow baseline PSA levelsProstate-specific antigen levelCancer Risk Assessment ProgramBaseline PSA levelsMedian PSA levelRisk of diagnosisBaseline risk scoreMedian risk scoreProstate cancer ratesProstate cancer diagnosisPrevious biopsyDairy intake and 1,25-dihydroxyvitamin D levels in men at high risk for prostate cancer
Tseng M, Giri V, Watkins-Bruner D, Giovannucci E. Dairy intake and 1,25-dihydroxyvitamin D levels in men at high risk for prostate cancer. Cancer Causes & Control 2009, 20: 1947-1954. PMID: 19578936, PMCID: PMC2895954, DOI: 10.1007/s10552-009-9389-9.Peer-Reviewed Original ResearchConceptsProstate cancerAssociation of dairyVitamin D intakeDihydroxyvitamin D levelsVitamin D statusProstate cancer riskHealth history questionnaireHigh-risk programD intakeD statusCalcium intakeHydroxyvitamin DAlcohol intakeD levelsDairy calciumDairy intakeInverse associationFood intakeCancer riskHigh riskConclusionOur findingsHistory questionnaireEnergy intakeMultivariate linear regressionIntake