2023
Liver Transplantation in a Woman with Mahvash Disease
Robbins J, Halegoua-DeMarzio D, Basu Mallick A, Vijayvergia N, Ganetzky R, Lavu H, Giri V, Miller J, Maley W, Shah A, DiMeglio M, Ambelil M, Yu R, Sato T, Lefler D. Liver Transplantation in a Woman with Mahvash Disease. New England Journal Of Medicine 2023, 389: 1972-1978. PMID: 37991855, DOI: 10.1056/nejmoa2303226.Peer-Reviewed Original ResearchConceptsPortal hypertensionLiver transplantationPancreatic hypertrophyMahvash diseasePancreatic α cell hyperplasiaAbsence of cirrhosisNoncirrhotic portal hypertensionΑ-cell hyperplasiaRare genetic disorderSerum glucagonDefinitive treatmentGlucagon levelsVascular diseaseMedical CenterHypertensionDiseaseAmmonia levelsHyperglucagonemiaGenetic disordersTransplantationHypertrophyGlucagonWomenHematemesisCirrhosis
2022
Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer
Thakker S, Loeb S, Giri V, Bjurlin M, Matulewicz R. Attitudes, Perceptions, and Use of Cancer-based Genetic Testing Among Healthy U.S. Adults and Those With Prostate or Breast/Ovarian Cancer. Urology Practice 2022, 10: 26-32. PMID: 37103438, DOI: 10.1097/upj.0000000000000352.Peer-Reviewed Original ResearchConceptsBreast/ovarian cancerHealth Information National Trends Survey 5Ovarian cancerProstate cancerGenetic testingCancer historyGenetic testing informationHistory of cancerHealthy U.S. adultsExposure of interestHealth care professionalsSelf-reported ratesEvidence-based informationPatient populationRepresentative sampleCare professionalsPatientsSecondary objectiveU.S. adultsCancerCommon sourceCategorical variablesSurvey 5Lack of awarenessCycle 4
2021
Predictors of Population Awareness of Cancer Genetic Tests: Implications for Enhancing Equity in Engaging in Cancer Prevention and Precision Medicine.
Giri V, Shimada A, Leader A. Predictors of Population Awareness of Cancer Genetic Tests: Implications for Enhancing Equity in Engaging in Cancer Prevention and Precision Medicine. JCO Precision Oncology 2021, 5: 1699-1708. PMID: 34778693, PMCID: PMC8585288, DOI: 10.1200/po.21.00231.Peer-Reviewed Original ResearchConceptsExact testCancer informationMultivariate logistic regression modelPopulation-based studyCross-sectional studyFisher's exact testPopulation-based sampleGenetic awarenessNational Trends SurveyNon-Hispanic whitesLogistic regression modelsPrecision medicine eraMiddle-high incomeDiverse population-based sampleCancer careModifiable factorsPersonalized cancer treatmentCancer preventionFemale genderHealth literacyCancer fatalismMedical literacyMultivariate analysisEthnic disparitiesGenetic testing
2019
Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men
Chandrasekar T, Gross L, Gomella L, Hegarty S, Leong J, Giri V. Prevalence of Suspected Hereditary Cancer Syndromes and Germline Mutations Among a Diverse Cohort of Probands Reporting a Family History of Prostate Cancer: Toward Informing Cascade Testing for Men. European Urology Oncology 2019, 3: 291-297. PMID: 31278035, DOI: 10.1016/j.euo.2019.06.010.Peer-Reviewed Original ResearchConceptsHereditary cancer syndromesProstate cancerCancer syndromesFamily historyGermline mutationsExact testHereditary breastGenetic testingAfrican AmericansPCa family historyAfrican American patientsOvarian cancer syndromeCascade genetic testingFisher's exact testHereditary prostate cancerBRCA mutationsLynch syndromeOvarian cancerSyndromeCancerCascade testingDiverse cohortAA participantsSpectrum of genesFHx
2018
Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing
Giri V, Hegarty S, Hyatt C, O'Leary E, Garcia J, Knudsen K, Kelly W, Gomella L. Germline genetic testing for inherited prostate cancer in practice: Implications for genetic testing, precision therapy, and cascade testing. The Prostate 2018, 79: 333-339. PMID: 30450585, DOI: 10.1002/pros.23739.Peer-Reviewed Original ResearchConceptsBreast cancer family historyCancer family historyProstate cancerFamily historyMetastatic diseaseGleason scoreExact testGenetic testingRetrospective cross-sectional analysisDNA repair genesCurrent NCCN guidelinesInherited prostate cancerGermline genetic testingHigh Gleason scoreFisher's exact testIdentification of menRepair genesPathogenic variant spectrumCross-sectional analysisFamily history dataGenetic testing capabilitiesNCCN guidelinesTherapeutic managementMultigene testingPV rates
2017
Prevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts
Truong H, Hegarty S, Gomella L, Kelly W, Trabulsi E, Lallas C, Giri V. Prevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts. Journal Of Genetic Counseling 2017, 26: 548-555. PMID: 28101821, DOI: 10.1007/s10897-016-0020-4.Peer-Reviewed Original ResearchConceptsRenal cell cancerReferral criteriaCell cancerReferral guidelinesDiagnosis of RCCConsensus criteriaInstitutional cancer registryCharacteristics of patientsReferral of patientsGenetic counselingChi-square testRate of whitesCross-sectional analysisCancer risk managementHereditary renal cell cancerSEER cohortWhite patientsBlack patientsInstitutional cohortRCC syndromesCancer RegistryPatient cohortKidney cancerAmerican CollegePatients
2015
High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort
Liu J, Parajuli S, Blackman E, Gibbs D, Ellis A, Hull A, Beck J, Giri V, Iherjirka P, Khurana J, Ragin C. High prevalence of discordant human papillomavirus and p16 oropharyngeal squamous cell carcinomas in an African American cohort. Head & Neck 2015, 38: e867-e872. PMID: 25962720, PMCID: PMC4643423, DOI: 10.1002/hed.24117.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaSquamous cell carcinomaAfrican American cohortPolymerase chain reactionAmerican cohortHPV- oropharyngeal squamous cell carcinomaHPV/p16 statusIncidence of HPVAfrican American patientsTumor RegistryCell carcinomaSCC cohortHuman papillomavirusP16 statusAmerican patientsP16 stainingTumor blocksHPVPatientsStandard immunohistochemistryTumor typesP16 negativityCohortChain reactionSurvival
2011
Familial Clustering of Sporadic Kidney Cancer: Insufficient Evidence to Recommend Routine Screening in Unaffected Kin
Smaldone M, Giri V, Uzzo R. Familial Clustering of Sporadic Kidney Cancer: Insufficient Evidence to Recommend Routine Screening in Unaffected Kin. European Urology 2011, 60: 994-995. PMID: 21741161, DOI: 10.1016/j.eururo.2011.06.026.Commentaries, Editorials and Letters
2008
Substantial family history of prostate cancer in black men recruited for prostate cancer screening
Mastalski K, Coups E, Ruth K, Raysor S, Giri V. Substantial family history of prostate cancer in black men recruited for prostate cancer screening. Cancer 2008, 113: 2559-2564. PMID: 18816608, PMCID: PMC2626163, DOI: 10.1002/cncr.23862.Peer-Reviewed Original ResearchConceptsFH of PCaProstate Cancer Risk Assessment ProgramNational Health Interview SurveyProstate cancerFamily historyBlack menCancer Risk Assessment ProgramMore first-degree relativesSelf-reported family historyMore family historyProstate cancer screeningHigh-risk menMen ages 35First-degree relativesHealth Interview SurveyAge-matched sampleSuboptimal screeningCancer screeningBreast cancerScreening programAge 35Colon cancerPCa screeningRisk assessment programCancerUsing Focus Groups to Adapt Ethnically Appropriate, Information-Seeking and Recruitment Messages for a Prostate Cancer Screening Program for Men at High Risk
Bryan C, Wetmore-Arkader L, Calvano T, Deatrick J, Giri V, Bruner D. Using Focus Groups to Adapt Ethnically Appropriate, Information-Seeking and Recruitment Messages for a Prostate Cancer Screening Program for Men at High Risk. Journal Of The National Medical Association 2008, 100: 674-682. PMID: 18595569, PMCID: PMC2700360, DOI: 10.1016/s0027-9684(15)31340-7.Peer-Reviewed Original Research
2005
Causes of Preventable Visual Loss in Type 2 Diabetes Mellitus
Hayward R, Cowan C, Giri V, Lawrence M, Makki F. Causes of Preventable Visual Loss in Type 2 Diabetes Mellitus. Journal Of General Internal Medicine 2005, 20: 467-469. PMID: 15963174, PMCID: PMC1490102, DOI: 10.1111/j.1525-1497.2005.40073.x.Peer-Reviewed Original ResearchConceptsAnnual retinal examinationPreventable visual lossLarge referral centerThird of casesPercent of casesRetinal examinationReferral centerVisual lossDiabetic retinopathyMedical recordsWasteful careRetinal photocoagulationType 2PatientsPhotocoagulationSuboptimal timingCurrent performance measuresThirdMellitusRetinopathyVisitsCareMonths