2024
TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing
Loeb S, Keith S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Hartman R, Brown L, Pieczonka C, Gomella L, Kelly W, Lallas C, Handley N, Mille P, Mark J, Brown G, Chopra S, McClellan A, Wise D, Hollifield L, Giri V. TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing. JCO Precision Oncology 2024, 8: e2300552. PMID: 38452310, PMCID: PMC10939575, DOI: 10.1200/po.23.00552.Peer-Reviewed Original ResearchMeSH KeywordsGenetic CounselingGenetic TestingGerm CellsHealth Knowledge, Attitudes, PracticeHumansMaleProstatic NeoplasmsConceptsGermline genetic testingDecisional conflictGenetic counselingProstate cancerPatient-drivenShortage of genetic counselorsKnowledge of cancer geneticsHereditary cancer riskReduce decisional conflictDecisional Conflict ScalePrimary outcome dataMixed-effects regression modelsDiverse patient populationsGenetic servicesClinical trial eligibilityGenetic counselorsGenetics educationPatient experienceCancer riskGermline testingAnalytical data setsCancer geneticsGermline evaluationConflict ScaleGenetic testing
2022
Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing
Loeb S, Cheng H, Leader A, Gross L, Nolasco T, Byrne N, Wise D, Hollifield L, Brown L, Slater E, Pieczonka C, Gomella L, Kelly W, Trabulsi E, Handley N, Lallas C, Chandrasekar T, Mille P, Mann M, Mark J, Brown G, Chopra S, Wasserman J, Phillips J, Somers P, Giri V. Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing. Contemporary Clinical Trials 2022, 119: 106821. PMID: 35710085, DOI: 10.1016/j.cct.2022.106821.Peer-Reviewed Original ResearchMeSH KeywordsAccelerationGenetic CounselingGenetic TestingGerm CellsHumansMaleProstatic NeoplasmsTechnologyConceptsKey patient-reported outcomesGermline testingPatient-reported outcomesProstate cancerGenetic counselingCollaborative care strategiesProstate cancer careTwo-armed randomizedProstate Cancer FoundationEducation/counselingGermline evaluationGOV IDENTIFIERPrimary outcomeSecondary outcomesStudy armsTarget enrollmentAshkenazi Jewish ancestryCancer careFamily historyTumor featuresCancer FoundationCare strategiesDecisional conflictUS sitesPractice settingsGermline testing and genetic counselling in prostate cancer
Russo J, Giri V. Germline testing and genetic counselling in prostate cancer. Nature Reviews Urology 2022, 19: 331-343. PMID: 35449224, PMCID: PMC9022414, DOI: 10.1038/s41585-022-00580-7.Peer-Reviewed Original ResearchMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingGerm CellsHumansMaleProstatic NeoplasmsConceptsProstate cancerCancer risk managementCancer riskGenetic testingHereditary cancer predisposition syndromesPre-test discussionUnique clinical featuresGermline pathogenic variantsPrecision medicineHealth care professionalsComplex management optionsAdditional cancer riskCancer predisposition syndromeHereditary cancer riskGenetic counsellingGermline testingMetastatic diseaseClinical featuresOptimal careMedical historyFamily historyPathogenic variantsPrecision therapyGene testingCancerGenetic testing in prostate cancer management: Considerations informing primary care
Giri V, Morgan T, Morris D, Berchuck J, Hyatt C, Taplin M. Genetic testing in prostate cancer management: Considerations informing primary care. CA A Cancer Journal For Clinicians 2022, 72: 360-371. PMID: 35201622, DOI: 10.3322/caac.21720.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansMalePrimary Health CareProstatic NeoplasmsConceptsNational Comprehensive Cancer Network guidelinesProstate cancerPrimary careGenetic testingNetwork guidelinesFamily historyClinical trial optionsGermline genetic testingMetastatic prostate cancerPrimary care providersMultidisciplinary patient careProstate cancer managementRole of cliniciansHereditary cancer riskMultiple professional societiesComprehensive family historyPC survivorsGermline testingPC screeningAggressive diseasePoor outcomePC careClinical pathwayCancer managementCancer riskWhen to use germline genetic testing in prostate cancer.
Giri V. When to use germline genetic testing in prostate cancer. Clinical Advances In Hematology And Oncology 2022, 20: 78-81. PMID: 35120087.Commentaries, Editorials and Letters
2021
Helix: A Digital Tool to Address Provider Needs for Prostate Cancer Genetic Testing in Clinical Practice
Giri V, Walker A, Gross L, Trabulsi E, Lallas C, Kelly W, Gomella L, Fischer C, Loeb S. Helix: A Digital Tool to Address Provider Needs for Prostate Cancer Genetic Testing in Clinical Practice. Clinical Genitourinary Cancer 2021, 20: e104-e113. PMID: 35012874, DOI: 10.1016/j.clgc.2021.11.009.Peer-Reviewed Original ResearchMeSH KeywordsGenetic CounselingGenetic TestingHumansMaleProstatic NeoplasmsRadiation OncologistsUrologistsConceptsGermline testingFamily historyClinical practiceChronic Diseases frameworkMultiple family historyMaternal family historyCancer genetic testingMedical oncologistsAdvanced PCaPCa riskProvider interviewsAggressive PCaRadiation oncologistsPractice settingsGenetic testingLarger studyDisease frameworkClinical useOncologistsLower ratesPractice gapMenDescriptive statisticsPhiladelphia areaProvidersPretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs
Russo J, McDougall C, Bowler N, Shimada A, Gross L, Hyatt C, Kelly W, Calvaresi A, Handley N, Hirsch I, Izes J, Lallas C, Mann M, Mark J, Mille P, Preate D, Trabulsi E, Tsang M, Chandrasekar T, Weiner P, Gomella L, Giri V. Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs. JCO Precision Oncology 2021, 5: 1377-1386. PMID: 34589662, PMCID: PMC8462590, DOI: 10.1200/po.21.00238.Peer-Reviewed Original ResearchConceptsGermline testingProstate cancerGenetic counselingDecisional conflictComparable patient-reported outcomesHereditary cancer assessmentPatient-reported outcomesCancer genetics knowledgePCa diagnosisPractice settingsPrecision careCancer assessmentInformed consentCategorical variablesSubstantial proportionGenetic knowledgeSignificant differencesContinuous variablesHigh rateMenPractice needsDescriptive statisticsProstate oncologyOutcomesCounselingGenetic Testing Guidelines and Education of Health Care Providers Involved in Prostate Cancer Care
Mark J, McDougall C, Giri V. Genetic Testing Guidelines and Education of Health Care Providers Involved in Prostate Cancer Care. Urologic Clinics Of North America 2021, 48: 311-322. PMID: 34210487, DOI: 10.1016/j.ucl.2021.03.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGermline testingProstate cancerGenetic testing guidelinesFirst-line therapyCastration-resistant diseaseEarly-stage diseaseProstate cancer careHealth care providersGenetic test resultsPCA careCancer careCare providersScreening settingCancer implicationsPARP inhibitorsTesting guidelinesPossible roleDiseaseCareMenPractice strategiesOncologistsTestingTherapyCancerBarriers and facilitators of germline genetic evaluation for prostate cancer
Loeb S, Li R, Nolasco T, Byrne N, Cheng H, Becker D, Leader A, Giri V. Barriers and facilitators of germline genetic evaluation for prostate cancer. The Prostate 2021, 81: 754-764. PMID: 34057231, DOI: 10.1002/pros.24172.Peer-Reviewed Original ResearchConceptsCoordination of careProstate cancerChronic Diseases frameworkGuideline-concordant careGermline testingMedical oncologistsPatient factorsPhysicians' knowledgePhysician educationRadiation oncologistsPractice settingsDisease frameworkThematic saturationGenetic counselingGenetic evaluationCareOncologistsRecent dataCancerConstant comparative methodInterview guidePhysiciansNumerous barriersQualitative studyInterview transcripts
2020
Physical activity assessment among men undergoing genetic counseling for inherited prostate cancer: a teachable moment for improved survivorship
Bruneau M, Milliron B, Sinclair E, Obeid E, Gross L, Bealin L, Smaltz C, Butryn M, Giri V. Physical activity assessment among men undergoing genetic counseling for inherited prostate cancer: a teachable moment for improved survivorship. Supportive Care In Cancer 2020, 29: 2145-2151. PMID: 32876733, PMCID: PMC7897228, DOI: 10.1007/s00520-020-05667-8.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesExerciseGenetic CounselingHumansMaleMiddle AgedProstatic NeoplasmsRisk FactorsSurvivorshipConceptsProstate cancerPA recommendationsPA adherenceModifiable cancer risk factorsOverweight/obesePhysical activity guidelinesCancer risk factorsAcademic cancer centerAdherence of participantsBody mass indexLogistic regression analysisPhysical activity assessmentIntensity of PATeachable momentActivity guidelinesCross-sectional designMass indexCancer CenterPCa statusPA guidelinesRisk factorsFamily historyChi-square analysisCancer survivorshipCancer risk
2019
Germline Genetic Testing in Advanced Prostate Cancer; Practices and Barriers: Survey Results from the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium
Paller CJ, Antonarakis ES, Beer TM, Borno HT, Carlo MI, George DJ, Graff JN, Gupta S, Heath EI, Higano CS, McKay RR, Morgans AK, Patnaik A, Petrylak DP, Rettig MB, Ryan CJ, Taplin ME, Whang YE, Vinson J, Cheng HH, Giri VN, Group P. Germline Genetic Testing in Advanced Prostate Cancer; Practices and Barriers: Survey Results from the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium. Clinical Genitourinary Cancer 2019, 17: 275-282.e1. PMID: 31171481, PMCID: PMC6662206, DOI: 10.1016/j.clgc.2019.04.013.Peer-Reviewed Original ResearchConceptsProstate Cancer Clinical Trials ConsortiumGermline genetic testingClinical Trials ConsortiumGenetic testingPCa patientsAdvanced prostate cancer patientsAdvanced prostate cancerMetastatic PCa patientsClinical trial eligibilityProstate cancer patientsPan-cancer panelCancer gene panelTrial eligibilityChoice of assayLocal diseaseCancer CenterAcademic oncologistsCancer patientsProstate cancerCancer treatment facilitiesPatientsBusy clinicPrecision therapyPersonalized treatmentWorking GroupGermline Testing for Men With Prostate Cancer: Navigating an Expanding New World of Genetic Evaluation for Precision Therapy and Precision Management
Giri V, Hyatt C, Gomella L. Germline Testing for Men With Prostate Cancer: Navigating an Expanding New World of Genetic Evaluation for Precision Therapy and Precision Management. Journal Of Clinical Oncology 2019, 37: jco.18.02181. PMID: 30978156, DOI: 10.1200/jco.18.02181.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDiet assessment among men undergoing genetic counseling and genetic testing for inherited prostate cancer: Exploring a teachable moment to support diet intervention
Milliron B, Bruneau M, Obeid E, Gross L, Bealin L, Smaltz C, Giri V. Diet assessment among men undergoing genetic counseling and genetic testing for inherited prostate cancer: Exploring a teachable moment to support diet intervention. The Prostate 2019, 79: 778-783. PMID: 30905089, PMCID: PMC8283914, DOI: 10.1002/pros.23783.Peer-Reviewed Original ResearchConceptsBody mass indexProstate cancerGenetic testingDiet interventionGenetic counselingStructured food frequency questionnaireCancer prevention goalsInherited prostate cancerFood frequency questionnaireUSDA recommendationsNumber of servingsHealthy lifestyle promotionLack of adherenceTeachable momentComplete survey dataFrequency questionnaireMass indexBMI classificationLess vegetablesPCa statusFamily historyNutrition interventionsDiet recommendationsCancer survivorshipCancer risk
2018
Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling
Giri V, Obeid E, Hegarty S, Gross L, Bealin L, Hyatt C, Fang C, Leader A. Understanding of multigene test results among males undergoing germline testing for inherited prostate cancer: Implications for genetic counseling. The Prostate 2018, 78: 879-888. PMID: 29655297, PMCID: PMC6047906, DOI: 10.1002/pros.23535.Peer-Reviewed Original ResearchConceptsInherited prostate cancerProstate cancerGenetic counselingGenetic testingMultivariable linear regressionFamily history dataPre-test genetic counselingHigh baseline knowledgeSyndrome criteriaGermline testingMultivariable analysisMultigene testingMedical recordsFamily historyCancer riskSubset of malesMcNemar testUncertain significanceGEM participantsHigher knowledgeMeasures of knowledgeGenetic resultsMenGT resultsBaseline knowledge
2017
The Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration.
Giri V, Yurgelun M, Robson M. The Role of Genetic Counseling in Familial and Sporadic Cancer: Considerations, Challenges, and Collaboration. Annals Of Internal Medicine 2017, 167: 884-885. PMID: 29086794, DOI: 10.7326/m17-2512.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts
Truong H, Hegarty S, Gomella L, Kelly W, Trabulsi E, Lallas C, Giri V. Prevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts. Journal Of Genetic Counseling 2017, 26: 548-555. PMID: 28101821, DOI: 10.1007/s10897-016-0020-4.Peer-Reviewed Original ResearchConceptsRenal cell cancerReferral criteriaCell cancerReferral guidelinesDiagnosis of RCCConsensus criteriaInstitutional cancer registryCharacteristics of patientsReferral of patientsGenetic counselingChi-square testRate of whitesCross-sectional analysisCancer risk managementHereditary renal cell cancerSEER cohortWhite patientsBlack patientsInstitutional cohortRCC syndromesCancer RegistryPatient cohortKidney cancerAmerican CollegePatients
2016
How I Do It: Genetic counseling and genetic testing for inherited prostate cancer.
Giri V, Gross L, Gomella L, Hyatt C. How I Do It: Genetic counseling and genetic testing for inherited prostate cancer. Canadian Journal Of Urology 2016, 23: 8247-53. PMID: 27085833.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansMalePedigreePractice Guidelines as TopicProstatic NeoplasmsConceptsProstate cancer patientsProstate cancerCancer patientsGenetic counselingProstate cancer risk assessmentGenetic testing guidelinesInherited prostate cancerHereditary cancer syndromesCancer risk assessmentProstate cancer predispositionFamily historyUrologic communityCancer syndromesCancerGenetic testingPatientsTesting guidelinesGenetic mutationsCounselingCancer predispositionUrologistsCurrent knowledgeSubstantial heritable componentGenetic contributionProviders
2014
Gene panel testing for inherited cancer risk.
Hall M, Forman A, Pilarski R, Wiesner G, Giri V. Gene panel testing for inherited cancer risk. Journal Of The National Comprehensive Cancer Network 2014, 12: 1339-46. PMID: 25190699, DOI: 10.6004/jnccn.2014.0128.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsGenetic CounselingGenetic Predisposition to DiseaseGenetic TestingHumansNeoplastic Syndromes, HereditaryPenetranceRisk