2023
PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study
Kaur M, Petersen G, Jekel L, von Reppert M, Varghese S, de Oliveira Santo I, Avesta A, Aneja S, Omuro A, Chiang V, Aboian M. PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study. Cancers 2023, 15: 4822. PMID: 37835516, PMCID: PMC10571649, DOI: 10.3390/cancers15194822.Peer-Reviewed Original ResearchPost-SRTStereotactic radiotherapyLung cancer brain metastasesCancer brain metastasesPost-contrast T1-weighted imagesSignificant clinical symptomsContrast-enhancing tumorT1-weighted imagesCritical additional informationEdema changesBrain metastasesClinical symptomsCare treatmentHyperintense volumeEdema assessmentLesion changesLesion sizeEdemaDifferent timepointsPilot studyRadiotherapyLesionsVolumetric changesAdditional informationMETS
2022
NIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY
Kaur M, Petersen G, von Reppert M, Jekel L, de Santo I, Varghese S, Chiang V, Aboian M. NIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661156, DOI: 10.1093/neuonc/noac209.624.Peer-Reviewed Original ResearchNSCLC brain metastasesPeritumoral edema volumeBrain metastasesEdema volumeLongest diameterGamma KnifeClinical practiceCE lesionsCommon intracranial malignancyStandard of careFLAIR hyperintense regionVolumetric measurementsIntracranial malignanciesEdema/Lung cancerTreatment responsePeritumoral volumesClinical informationPeritumoral edemaLongitudinal assessmentTreatment assessmentNeuroradiology practiceHyperintense regionsMetastasisLesionsNIMG-07. APPLYING A GLIOMA-TRAINED DEEP LEARNING AUTO-SEGMENTATION TOOL ON BM PRE- AND POST-RADIOSURGERY
Kaur M, Varghese S, Jekel L, Tillmanns N, Merkaj S, Bousabarah K, Lin M, Bhawnani J, Chiang V, Aboian M. NIMG-07. APPLYING A GLIOMA-TRAINED DEEP LEARNING AUTO-SEGMENTATION TOOL ON BM PRE- AND POST-RADIOSURGERY. Neuro-Oncology 2022, 24: vii162-vii163. PMCID: PMC9660643, DOI: 10.1093/neuonc/noac209.626.Peer-Reviewed Original ResearchStereotactic radiosurgeryPosttreatment lesionsBoard-certified neuroradiologistsRoutine clinical useWhole tumorTumor coreMulticentric lesionsTreatment responsePeritumoral edemaBM preLesionsClinical useVolumetric segmentationEdemaPatientsT2w FLAIRTherapy planningTumorsDedicated trainingLesion detectionBM dataVolumetric measurementsBMMRIPreSynchronous glioblastoma and brain metastases: illustrative case
Shahsavari N, Ahmad M, Sekar V, Meola A, Hancock SL, Chang SD, Chiang VL. Synchronous glioblastoma and brain metastases: illustrative case. Journal Of Neurosurgery Case Lessons 2022, 3: case21714. PMID: 36273867, PMCID: PMC9379681, DOI: 10.3171/case21714.Peer-Reviewed Original ResearchBrain metastasesMultiple brain metastasesRadiosurgical treatmentSignificant perilesional edemaSimilar radiological featuresMetastatic lung adenocarcinomaRight temporal lobeStereotactic radiosurgical treatmentMaintenance nivolumabRadiological featuresMidline shiftPerilesional edemaTreatment courseTissue confirmationLung adenocarcinomaStereotactic radiosurgeryTemporal lobeMetastasisIllustrative caseIncorrect diagnosisRadiological surveillanceSynchronous presenceIDH-wildtypeGlioblastomaLesionsReal-time PACS-integrated longitudinal brain metastasis tracking tool provides comprehensive assessment of treatment response to radiosurgery
Petersen G, Bousabarah K, Verma T, von Reppert M, Jekel L, Gordem A, Jang B, Merkaj S, Fadel S, Owens R, Omuro A, Chiang V, Ikuta I, Lin M, Aboian MS. Real-time PACS-integrated longitudinal brain metastasis tracking tool provides comprehensive assessment of treatment response to radiosurgery. Neuro-Oncology Advances 2022, 4: vdac116. PMID: 36043121, PMCID: PMC9412827, DOI: 10.1093/noajnl/vdac116.Peer-Reviewed Original ResearchGamma KnifeTreatment responseBrain metastasis patientsFurther treatment planningNumber of lesionsMean followBrain metastasesMetastasis patientsMultiple lesionsDiagnostic followSingle patientStereotactic radiosurgeryPatientsLesionsIndividual lesionsPrevalenceAccurate surveillanceHeterogenous responseTreatment planningTreatmentFollowRadiosurgerySize assessmentComprehensive assessmentResponse
2021
Recognition and Management of Adverse Radiation Effects
Cheok S, Hansen J, Chiang V. Recognition and Management of Adverse Radiation Effects. 2021, 391-404. DOI: 10.1201/9781003167464-36.ChaptersAdverse radiation effectsRadiation necrosisStereotactic radiosurgeryRole of SRSImmune-mediated componentLaser interstitial thermotherapyMore brain lesionsBrain metastasesSystemic therapyIntracranial pathologyMalignant pathologyBrain lesionsNecrosisInterstitial thermotherapyPathologyContemporary evidenceBevacizumabCraniotomyMetastasisTherapyLesionsRadiosurgerySteroids
2020
Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Robert S, Chiang V. Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases. 2020, 393-405. DOI: 10.1007/978-3-030-42958-4_28.ChaptersMetastatic brain lesionsRadiation necrosisBrain lesionsStereotactic radiosurgeryRadiation-induced side effectsImmune system involvementEffective treatment modalityMetastatic intracranial tumorsBrain metastasesSystemic cancerTreatment modalitiesUnderlying pathophysiologySystem involvementDisease entityIntracranial tumorsRadiosurgical treatmentSide effectsTumor progressionBrain tissueNecrosisConcurrent useLesionsRadiosurgeryImaging modalitiesLife expectancy
2019
MLTI-06. BEVACIZUMAB VERSUS SURGICAL INTERVENTION FOR RADIATION NECROSIS IN PREVIOUSLY IRRADIATED BRAIN METASTASES
Hong C, Sujijantarat N, Chiang V. MLTI-06. BEVACIZUMAB VERSUS SURGICAL INTERVENTION FOR RADIATION NECROSIS IN PREVIOUSLY IRRADIATED BRAIN METASTASES. Neuro-Oncology Advances 2019, 1: i15-i15. PMCID: PMC7213266, DOI: 10.1093/noajnl/vdz014.065.Peer-Reviewed Original ResearchProgression-free survivalLaser interstitial thermal ablationBrain metastasesRadiation necrosisOverall survivalSurgical managementSurgical interventionSingle-institution chart reviewTime of interventionInterstitial thermal ablationBevacizumab cohortGood KPSLower KPSBevacizumab therapySurgery cohortChart reviewMedical managementTrue efficacyBevacizumabComparative outcomesPatientsLesionsComparison groupThermal ablationIntervention
2016
Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment
Cohen JV, Alomari AK, Vortmeyer AO, Jilaveanu LB, Goldberg SB, Mahajan A, Chiang VL, Kluger HM. Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment. Cancer Immunology Research 2016, 4: 179-182. PMID: 26701266, PMCID: PMC4881844, DOI: 10.1158/2326-6066.cir-15-0160.Peer-Reviewed Original ResearchConceptsCentral nervous systemBrain metastasesActive brain lesionsNew immunomodulating agentsImmune checkpoint inhibitorsRole of immunotherapyPembrolizumab treatmentCheckpoint inhibitorsCNS lesionsReactive astrocytosisImmune suppressionPerilesional edemaInflammatory cellsMicroglial cellsImmunomodulating agentMental statusBrain lesionsHistologic evaluationMost trialsNervous systemCentral enhancementTumor cellsPatientsMetastasisLesions
2015
Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions.
Jairam V, Chiang VL, Bond J, Yu JB. Equivalent whole brain dose for patients undergoing gamma knife for multiple lesions. Journal Of Radiosurgery And SBRT 2015, 3: 187-191. PMID: 29296401, PMCID: PMC5746333.Peer-Reviewed Original ResearchWhole-brain doseTotal tumor volumeMultiple lesionsTumor volumeBrain doseMedian total tumor volumeCumulative tumor volumeWhole brain dosesWhole brain radiotherapyTreatment of patientsBrain metastasesBrain radiotherapyIndividualized treatment planningTumor numberBrain dosesInstitutional databaseTumor locationMedian numberRadiosurgical treatmentPatientsRepresentative patientsLesionsEntire brainVital structuresGamma Knife
2014
Significance of histology in determining management of lesions regrowing after radiosurgery
Nath SK, Sheridan AD, Rauch PJ, Yu JB, Minja FJ, Vortmeyer AO, Chiang VL. Significance of histology in determining management of lesions regrowing after radiosurgery. Journal Of Neuro-Oncology 2014, 117: 303-310. PMID: 24504499, DOI: 10.1007/s11060-014-1389-2.Peer-Reviewed Original ResearchConceptsBrain metastasesTumor cellsLocal controlSignificance of histologyWorse local controlResidual tumor cellsPost-treatment imagingManagement of lesionsOngoing patient managementInflammatory changesClinical outcomesResidual tumorSymptomatic enlargementAmbiguous etiologyHistologic findingsPatient outcomesPatient managementBrain specimensStereotactic radiosurgeryHistopathologic interpretationLesionsTissue specimensResectionPatientsMetastasisMass Effect
Chiang V, Awad I. Mass Effect. 2014, 1007-1008. DOI: 10.1016/b978-0-12-385157-4.00765-x.Peer-Reviewed Original ResearchMass effectSuch mass lesionsDisturbance of consciousnessTreatment of choiceCompression of vesselsCentral nervous systemCerebrospinal fluid flowSecondary hydrocephalusVisual obscurationsMass lesionSurgical removalVascular lesionsGeneral symptomsIntracranial pressureExtrinsic pathologiesSpecific symptomsNervous systemNeuronal tissueLesionsSymptomsPossible obstructionFocal distortionVomitingHematomaIschemia
2013
Advances in therapy for melanoma brain metastases
Flanigan JC, Jilaveanu LB, Chiang VL, Kluger HM. Advances in therapy for melanoma brain metastases. Clinics In Dermatology 2013, 31: 264-281. PMID: 23608446, DOI: 10.1016/j.clindermatol.2012.08.008.Peer-Reviewed Original Research
2012
Management of Brain Metastases Surgery, Radiation, or Both?
Patel TR, Knisely JP, Chiang VL. Management of Brain Metastases Surgery, Radiation, or Both? Hematology/Oncology Clinics Of North America 2012, 26: 933-947. PMID: 22794291, DOI: 10.1016/j.hoc.2012.04.008.Peer-Reviewed Original ResearchTracking Metastatic Brain Tumors in Longitudinal Scans via Joint Image Registration and Labeling
Chitphakdithai N, Chiang VL, Duncan JS. Tracking Metastatic Brain Tumors in Longitudinal Scans via Joint Image Registration and Labeling. Lecture Notes In Computer Science 2012, 7570: 124-136. PMID: 31187098, PMCID: PMC6559745, DOI: 10.1007/978-3-642-33555-6_11.Peer-Reviewed Original Research
2011
A Comprehensive Review of MR Imaging Changes following Radiosurgery to 500 Brain Metastases
Patel TR, McHugh BJ, Bi WL, Minja FJ, Knisely JP, Chiang VL. A Comprehensive Review of MR Imaging Changes following Radiosurgery to 500 Brain Metastases. American Journal Of Neuroradiology 2011, 32: 1885-1892. PMID: 21920854, PMCID: PMC7966021, DOI: 10.3174/ajnr.a2668.Peer-Reviewed Original ResearchConceptsBrain metastasesMedian survivalMetastatic lesionsLesion sizeMost metastatic lesionsMR imaging changesPercent of lesionsInitial treatment volumeSystemic cancer therapyInitial lesion sizeIntracranial metastatic lesionsGK-SRSLesional responsePatient demographicsRadiographic responseInitial treatmentImaging changesMale sexTumor sizeLesion volumeStereotactic radiosurgeryTreatment dosePatientsLesionsRadiosurgeryImplications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery
Patel TR, Ozturk AK, Knisely JP, Chiang VL. Implications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery. International Journal Of Surgical Oncology 2011, 2012: 748284. PMID: 22312543, PMCID: PMC3265271, DOI: 10.1155/2012/748284.Peer-Reviewed Original ResearchMagnetic resonance imagingNumber of metastasesAdditional metastasesGamma knife radiosurgeryGK-SRSCerebral metastasesAdditional lesionsKnife radiosurgeryProgressive systemic diseaseTreatment magnetic resonance imagingKaplan-Meier analysisImportant prognostic informationMedian survivalRetrospective reviewIntracranial metastasesSystemic diseasePrognostic informationMetastasisPatientsResonance imagingLesionsRadiosurgeryMonthsDaysDisease
2005
Interventional Neuroradiology Adjuncts and Alternatives in Patients with Head and Neck Vascular Lesions
Johnson MH, Chiang VL, Ross DA. Interventional Neuroradiology Adjuncts and Alternatives in Patients with Head and Neck Vascular Lesions. Neurosurgery Clinics Of North America 2005, 16: 547-560. PMID: 15990044, DOI: 10.1016/j.nec.2005.04.007.Peer-Reviewed Original ResearchConceptsEndovascular techniquesVascular lesionsEndovascular transarterial embolizationGroup of patientsNeck vascular lesionsManagement of lesionsIschemic deficitsNeurologic symptomsPreoperative managementTransarterial embolizationSevere headVertebral arteryVascular injuryTolerance testPerioperative settingPatient managementSalvage measureSkull baseTraumatic conditionsVascular structuresLesionsPatientsNeckHeadEmbolization