Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response
Lin Y, Xie M, Lau H, Zeng R, Zhang R, Wang L, Li Q, Wang Y, Chen D, Jiang L, Damsky W, Yu J. Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response. Med 2024 PMID: 39515321, DOI: 10.1016/j.medj.2024.10.007.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsMicrobial biomarkersPredicting ICI responseGut microbiotaICI responseMulti-cancersEffects of gut microbiotaCheckpoint inhibitorsModulating CD8<sup>+</sup> T cells activityCD8<sup>+</sup> T cell activationICI respondersImmune checkpoint inhibitor recipientsPredictors of ICI responseImmune checkpoint inhibitor efficacyHungatella hathewayiCancer typesFecal metagenomesGut bacteriaSignature speciesT cell activationMicrobiota compositionF. prausnitziiPredicting therapeutic responseWilcoxon rank testMicrobiota