Skip to Main Content

William J. Kim, PhD

Assistant Professor
DownloadHi-Res Photo

About

Titles

Assistant Professor

Biography

Dr. William Kim has demonstrated a passion for interdisciplinary collaboration. His research leverages advanced computational and data-driven approaches alongside genome engineering technologies to contribute to advancing our understanding of cancer. Kim received his PhD from Duke University and the Institute for Genome Sciences Policy, where he received support from the Department of Defense Breast Cancer Research Predoctoral Program and the Korean Science & Engineering Foundation Award.

Following his doctoral work, Kim joined the Dana Farber Cancer Institute and the Broad Institute of Harvard and MIT for his postdoctoral research. There, he made significant contributions to developing novel computational approaches for the systematic characterization of cancer genomes and oncogenic cellular states. He also discovered a novel role for the Protein phosphatase 2A (PP2A) enzyme in oncogenic transformation, expanding the understanding of this important signaling pathway.

Leveraging his expertise in cancer biology and computational biology, Kim then joined the University of California San Diego (UCSD) School of Medicine in the Division of Genomics and Precision Medicine. At UCSD, he co-led a multidisciplinary team of researchers, clinicians, patients, and community advocates on a California Initiative for Precision Medicine Project, supported by the California Governor's Office. Kim also served as the Co-Director of the UCSD Center for Cancer Target Discovery and Development (CTD2), further driving the integration of data-driven and biological approaches to cancer research.

William Kim joined the Department of Urology at Yale University School of Medicine. Here, he aims to bridge the gap between cancer biology and data science, working towards a comprehensive understanding of cellular circuitry and the realization of the full potential of cancer precision medicine.

Appointments

  • Urology

    Assistant Professor
    Primary

Other Departments & Organizations

Research

Overview

The Kim lab employs systematic approaches to study cancer, with the goal of discovering the most effective strategies for prevention and treatment. Our methodology involves 1) comprehensive assessment of oncogenic programs in cancers using integrated machine-learning techniques, 2) deep interrogation of molecular changes in response to pharmacological and genetic perturbations, and 3) reconstruction and reverse engineering of cancer cells to create better models of the disease. These approaches will enhance our understanding of cancer as a complex system, ultimately guiding the development of strategies that maximize therapeutic efficacy while minimizing drug resistance and disease recurrence in patients.

Medical Subject Headings (MeSH)

Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Cellular Reprogramming; Computational Biology; Gene Expression; Health Inequities; Machine Learning; Multiomics; Neoplasms; Oncogene Addiction; Precision Medicine; Translational Science, Biomedical

Research at a Glance

Research Interests

Research topics William J. Kim is interested in exploring.

Publications

2024

2023

2022

2021

2020

Get In Touch