Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature
Kaseb H, Tan C, Townsend J, Costa J, Laskin W. Genomic Landscape of Osteosarcoma of Bone in an Older-Aged Patient Population and Analysis of Possible Etiologies Based on Molecular Signature. Genetic Testing And Molecular Biomarkers 2024, 28: 351-359. PMID: 39052504, DOI: 10.1089/gtmb.2024.0080.Peer-Reviewed Original ResearchWhole-exome sequencingTumor mutational burdenOsteosarcoma of boneMutational burdenGenomic landscapeDNA damage repair genesDNA homologous recombination repairLoss of heterozygosityEffects of chemotherapyPathogenic germline mutationsParaffin-embedded tissuesPrimary malignant bone tumorAnalysis of single nucleotide variantsMalignant bone tumorsRecombination repairMutagenic processesMolecular aberrationsOlder adult patientsAdult patientsSingle nucleotide variantsDNA recombinational repairGermline mutationsTumor pathogenesisFormalin-fixedHomologous recombination repair