2020
A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin
Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsSmooth muscle cellsICC hyperplasiaMuscle cellsTyrosine kinase inhibitor imatinibFrequent driver eventsCommon mesenchymal tumorsSmooth muscle cell progenitorsDevelopment of GISTsKinase inhibitor imatinibLoss of Trp53ICC-DMPGut motilityStromal tumorsMesenchymal tumorsMouse modelInhibitor imatinibInterstitial cellsMutant BRAFBRAF expressionTumorsBRAFHyperplasiaCell progenitorsDriver events
2017
In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous
Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Archiv 2017, 470: 545-552. PMID: 28213807, PMCID: PMC5623953, DOI: 10.1007/s00428-017-2093-3.Peer-Reviewed Original ResearchConceptsSmall intestinal neuroendocrine tumorsLiver metastasesSSTR2A expressionIntestinal neuroendocrine tumorsKi67 indexNeuroendocrine tumorsPrimary tumorLiver tumorsMetastatic small intestinal neuroendocrine tumorsMore liver lesionsMost liver tumorsCorresponding liver metastasesMore liver tumorsFormalin-fixed paraffin-embedded sectionsParaffin-embedded sectionsMetastatic lesionsMetastatic tumorsSI-NETsSame patientLiver lesionsIHC scoreMetastasisScoring systemSignificant associationTumor tissue