2018
Adipocyte OGT governs diet-induced hyperphagia and obesity
Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nature Communications 2018, 9: 5103. PMID: 30504766, PMCID: PMC6269424, DOI: 10.1038/s41467-018-07461-x.Peer-Reviewed Original ResearchConceptsSerine/threonine residuesN-acetylglucosamine transferaseNutrient cuesThreonine residuesTranscriptional activationO-GlcNAcylationLipid desaturationIntracellular proteinsOGTHigh-fat diet-induced hyperphagiaDevelopment of obesityBaseline food intakeSignaling contributesLipid signalsCB1 signalingBrain axisChronic dysregulationFood intakeMetabolic diseasesPalatable foodPharmacological manipulationHyperphagiaObesityFat sensorSignaling
2002
Recruitment of O-GlcNAc Transferase to Promoters by Corepressor mSin3A Coupling Protein O-GlcNAcylation to Transcriptional Repression
Yang X, Zhang F, Kudlow JE. Recruitment of O-GlcNAc Transferase to Promoters by Corepressor mSin3A Coupling Protein O-GlcNAcylation to Transcriptional Repression. Cell 2002, 110: 69-80. PMID: 12150998, DOI: 10.1016/s0092-8674(02)00810-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimal Population GroupsAnimalsCOS CellsGene Expression RegulationGene SilencingGenes, ReporterGlycoproteinsHistone DeacetylasesHumansN-AcetylglucosaminyltransferasesPromoter Regions, GeneticRepressor ProteinsSin3 Histone Deacetylase and Corepressor ComplexTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsRNA polymerase IIPolymerase IIGlcNAc transferaseHistone deacetylationTranscription factorsN-acetylglucosamine monosaccharidesHistone deacetylase complexO-GlcNAc modificationProtein O-GlcNAcylationDeacetylase complexTranscriptional repressionThreonine residuesPrecise functional rolePosttranslational modificationsO-GlcNAcylationFunctional roleSpecific mannerMSin3AOGTPromoterDeacetylationTransferaseCorepressorTranscriptionRepression