Lip, Oral Cavity and Pharynx, Phase I-II

A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Standard of Care Therapeutic Agents in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Volunteers
Health Professionals

What is the purpose of this trial?

The purpose of this study is to determine safety and preliminary efficacy of amivantamab monotherapy, amivantamab in addition to pembrolizumab, and amivantamab in addition to paclitaxel in participants with recurrent/metastatic head and neck cancer. The study will also confirm the recommended Phase 2 combination dose (RP2CD) for amivantamab in addition to paclitaxel.

Trial with
Janssen Research & Development, LLC
Ages
18 years and older
Gender
Both

Find out more about who can participate in this trial

Contact Information

For more information about this study, including how to volunteer, contact Anna Wu

anna.wu@yale.edu

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Principal Investigator

Aarti Bhatia, MD, MPH
Associate Professor of Medicine (Medical Oncology); Clinical Research Team Leader, Head and Neck Cancers Program

Sub-Investigators

Last Updated
12/13/2024
Study HIC
#2000037457