A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type.
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Principal Investigator
Sub-Investigators
- Allison Campbell, MD, PhD
- Anca Bulgaru, MD
- Andrea Brennan
- Armand Russo, MD
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Bruce A. McGibbon, MD
- Clarice Grens
- D. Barry Boyd, MD, MS
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Henry S. Park, MD, MPH
- Jacquelyne Gaddy, MD, MSc, MSCR
- James Laird, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Jill Lacy, MD
- Johanna LaSala, MD
- Justin Persico, MD
- Katelyn Scott
- Kimberly L. Johung, MD, PhD
- Kristen Hoxie
- Larisa Fleysher
- Laura Van Metre Baum, MD, MPH
- M. Sung Lee, MD
- Matthew Austin, MD
- Michael Cecchini, MD
- Michael Cohenuram, MD
- Neal Fischbach, MD
- Pamela L. Kunz, MD
- Rebecca Vanasse-Passas, MD
- Renee Moye
- Robert Legare, MD
- Sara Anastasio, RN
- Sarah Carlson
- Stacey Stein, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Susan Gueble, MD, PhD
- Teresa White
- Thejal Srikumar, MD, MPH
- Thomas Hayman, MD, PhD
- Vanna Dest
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Last Updated09/24/2024
- Study HIC#2000037486