Targeted Treatment for Advanced Non-Small Cell Lung Cancer that has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period of improvement (recurrent). Tepotinib is used in patients whose cancer has a mutated (changed) form of a gene called MET. It is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal MET protein that signals tumor cells to multiply. This helps slow or stop the spread of tumor cells. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Giving tepotinib with ramucirumab may lower the chance of the cancer from growing or spreading in patients with stage IV or recurrent non-small cell lung cancer.
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Principal Investigator
Sub-Investigators
- Anca Bulgaru, MD
- Andrea Brennan
- Anne Chiang, MD, PhD
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Christi Kim, MD, FACP
- D. Barry Boyd, MD, MS
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Emily Collier, MD
- Emily Kopas, APRN, OCN
- Frederick Wilson, MD, PhD
- Harold Tara Jr, MD
- Jade Vanacore
- James Vredenburgh, MD
- Jason Haldas, MD
- Johanna LaSala, MD
- John Glendening
- Jose Morales-Marin
- Karishma Mehra, MBBS
- Katherine Harvey, MD, MPH
- Kert Sabbath, MD, FACP
- Laura Sabourin
- M. Sung Lee, MD
- Marianne Davies, NP, DNP, MSN, BSN
- Matthew Austin, MD
- Michael Cohenuram, MD
- Pawan Karanam, MD
- Robert Legare, MD
- Roy S. Herbst, MD, PhD
- Sara Farisello
- Sarah Goldberg, MD, MPH
- Sarah Elizabeth Schellhorn, MD
- Scott Gettinger, MD
- Sharynn Hall, MD, PhD
- So Yeon Kim, MD
- Stephen Lattanzi, MD
- Su Hsien Lim, MD
- Vanna Dest
- Victor Chang, MD
- Vidya Kesavan
- Wajih Kidwai, MD, FACP
- Yifei Zhang, MD
- Zia Rahman, MD
- Last Updated08/05/2024
- Study HIC#2000036990